BAIT
EHBP1L1
G430002G23Rik
EH domain binding protein 1-like 1
GO Process (0)
GO Function (0)
GO Component (0)
Mus musculus
PREY
BIN1
ALP-1, Amphl, BRAMP-2, SH3P9
bridging integrator 1
GO Process (8)
GO Function (7)
GO Component (14)
Gene Ontology Biological Process
- lipid tube assembly [ISO]
- muscle cell differentiation [IMP]
- positive regulation of GTPase activity [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of astrocyte differentiation [ISO]
- positive regulation of endocytosis [ISO]
- regulation of cell cycle arrest [ISO]
- regulation of neuron differentiation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
EHBP1L1 coordinates Rab8 and Bin1 to regulate apical-directed transport in polarized epithelial cells.
The highly conserved Rab guanosine triphosphatase (GTPase) Rab8 plays a role in exocytosis toward the polarized plasma membrane in eukaryotic cells. In murine Rab8-deficient small intestine cells, apical proteins are missorted into lysosomes. In this study, we identified a novel Rab8-interacting protein complex containing an EH domain-binding protein 1-like 1 (EHBP1L1), Bin1/amphiphysin II, and dynamin. Biochemical analyses showed that EHBP1L1 ... [more]
J. Cell Biol. Feb. 01, 2016; 212(3);297-306 [Pubmed: 26833786]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| EHBP1L1 BIN1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID