BAIT
AGTR1A
AT1, AT1A, AT1R, Agtr1
angiotensin II receptor, type 1a
GO Process (40)
GO Function (10)
GO Component (15)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IMP, ISO]
- Rho protein signal transduction [ISO]
- activation of Janus kinase activity [IMP]
- aging [IEP]
- angiotensin-activated signaling pathway [ISO]
- blood vessel development [ISO]
- brain renin-angiotensin system [ISO]
- calcium-mediated signaling [ISO]
- cell chemotaxis [ISO]
- cellular response to dexamethasone stimulus [IDA]
- dopamine biosynthetic process [IMP]
- drinking behavior [IMP, ISO]
- heart development [ISO]
- inflammatory response [ISO]
- kidney development [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of smooth muscle cell apoptotic process [ISO]
- phospholipase C-activating G-protein coupled receptor signaling pathway [IDA]
- phospholipase C-activating angiotensin-activated signaling pathway [IDA, IMP, ISO]
- positive regulation of blood pressure [IMP, ISO]
- positive regulation of branching involved in ureteric bud morphogenesis [IMP]
- positive regulation of cell proliferation [IMP, ISO]
- positive regulation of cellular protein metabolic process [ISO]
- positive regulation of cholesterol esterification [ISO]
- positive regulation of cytokine secretion [ISO]
- positive regulation of cytosolic calcium ion concentration [IDA, ISO]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [ISO]
- positive regulation of phospholipase A2 activity [ISO]
- positive regulation of receptor recycling [IDA]
- positive regulation of superoxide anion generation [IMP]
- regulation of blood pressure [TAS]
- regulation of pH [IDA]
- regulation of renal output by angiotensin [ISO]
- regulation of smooth muscle cell apoptotic process [ISO]
- regulation of systemic arterial blood pressure by circulatory renin-angiotensin [ISO]
- regulation of vasoconstriction [ISO]
- renin secretion into blood stream [ISO]
- renin-angiotensin regulation of aldosterone production [IMP, ISO]
- response to estrogen [IDA, IEP]
- vasoconstriction [IMP]
Gene Ontology Molecular Function- D1 dopamine receptor binding [IPI]
- G-protein alpha-subunit binding [IMP]
- angiotensin type I receptor activity [IDA, IMP, ISO]
- angiotensin type II receptor activity [ISO]
- bradykinin receptor binding [ISO]
- peptide hormone binding [IMP]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein kinase binding [IPI]
- protein self-association [IMP]
- D1 dopamine receptor binding [IPI]
- G-protein alpha-subunit binding [IMP]
- angiotensin type I receptor activity [IDA, IMP, ISO]
- angiotensin type II receptor activity [ISO]
- bradykinin receptor binding [ISO]
- peptide hormone binding [IMP]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein kinase binding [IPI]
- protein self-association [IMP]
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- basolateral plasma membrane [IDA]
- cell [ISO]
- cytoplasm [ISO]
- cytoplasmic vesicle [IDA]
- dendrite [IDA]
- endomembrane system [IDA]
- endosome [ISO]
- integral component of membrane [TAS]
- membrane [IDA]
- organelle outer membrane [IDA]
- plasma membrane [IDA, ISO]
- recycling endosome [IDA]
- vesicle lumen [IDA]
- vesicle membrane [IDA]
Rattus norvegicus
PREY
AGT
ANRT, Ang, AngII, PAT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
GO Process (88)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- ERK1 and ERK2 cascade [IDA]
- G-protein coupled receptor signaling pathway [IMP, ISO]
- activation of NF-kappaB-inducing kinase activity [ISO]
- activation of phospholipase C activity [IMP]
- aging [IEP]
- angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure [ISO]
- angiotensin-mediated drinking behavior [IDA, IMP]
- artery smooth muscle contraction [IDA]
- astrocyte activation [ISO]
- blood vessel development [ISO]
- brain renin-angiotensin system [ISO]
- branching involved in ureteric bud morphogenesis [ISO]
- catenin import into nucleus [IDA]
- cell growth involved in cardiac muscle cell development [IDA]
- cell surface receptor signaling pathway [IDA]
- cell-matrix adhesion [ISO]
- cellular response to mechanical stimulus [IEP]
- cellular sodium ion homeostasis [IMP]
- cytokine secretion [IDA]
- drinking behavior [ISO]
- establishment of blood-nerve barrier [ISO]
- excretion [ISO]
- extracellular matrix organization [ISO]
- female pregnancy [IEP]
- fibroblast proliferation [IDA]
- hormone metabolic process [ISO]
- kidney development [ISO]
- negative regulation of angiogenesis [IDA]
- negative regulation of cell growth [IMP]
- negative regulation of cell proliferation [ISO]
- negative regulation of endopeptidase activity [IBA]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of neurotrophin TRK receptor signaling pathway [ISO]
- negative regulation of tissue remodeling [IDA]
- ovarian follicle rupture [ISO]
- peristalsis [ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of activation of JAK2 kinase activity [ISO]
- positive regulation of blood pressure [IDA]
- positive regulation of branching involved in ureteric bud morphogenesis [ISO]
- positive regulation of cardiac muscle hypertrophy [IDA]
- positive regulation of catalytic activity [IMP]
- positive regulation of cell proliferation [IDA]
- positive regulation of cellular protein metabolic process [ISO]
- positive regulation of cholesterol esterification [ISO]
- positive regulation of endothelial cell migration [ISO]
- positive regulation of epidermal growth factor receptor signaling pathway [ISO]
- positive regulation of extracellular matrix constituent secretion [IDA]
- positive regulation of extrinsic apoptotic signaling pathway [ISO]
- positive regulation of fatty acid biosynthetic process [ISO]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of gene expression [ISO]
- positive regulation of multicellular organism growth [ISO]
- positive regulation of nitric oxide biosynthetic process [IDA]
- positive regulation of organ growth [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein kinase C activity [ISO]
- positive regulation of protein tyrosine kinase activity [ISO]
- positive regulation of renal sodium excretion [IDA, IMP]
- positive regulation of superoxide anion generation [IDA]
- positive regulation of transcription, DNA-templated [ISO]
- positive regulation of vasodilation [IDA]
- regulation of apoptotic process [ISO]
- regulation of blood pressure [ISO]
- regulation of calcium ion transport [IDA]
- regulation of gene expression [ISO]
- regulation of inflammatory response [ISO]
- regulation of long-term neuronal synaptic plasticity [IMP]
- regulation of norepinephrine secretion [IMP]
- regulation of proteolysis [IBA]
- regulation of renal output by angiotensin [ISO]
- regulation of renal sodium excretion [IDA]
- regulation of systemic arterial blood pressure by circulatory renin-angiotensin [ISO]
- regulation of transmission of nerve impulse [IDA]
- renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure [ISO]
- renal system process [ISO]
- renin-angiotensin regulation of aldosterone production [IDA, ISO]
- response to cold [ISO]
- response to muscle activity involved in regulation of muscle adaptation [IMP]
- response to salt stress [ISO]
- smooth muscle cell differentiation [ISO]
- smooth muscle cell proliferation [IDA, ISO]
- stress-activated MAPK cascade [IDA]
- uterine smooth muscle contraction [IDA]
- vasoconstriction [IDA]
- vasodilation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
A conserved NPLFY sequence contributes to agonist binding and signal transduction but is not an internalization signal for the type 1 angiotensin II receptor.
A conserved NPX2-3Y sequence that is located in the seventh transmembrane helix of many G protein-coupled receptors has been predicted to participate in receptor signaling and endocytosis. The role of this sequence (NPLFY) in angiotensin II receptor function was studied in mutant and wild-type rat type 1a angiotensin II receptors transiently expressed in COS-7 cells. The ability of the receptor ... [more]
J. Biol. Chem. Jul. 14, 1995; 270(28);16602-9 [Pubmed: 7622467]
Throughput
- Low Throughput
Additional Notes
- Cell membranes expressing 24180 were exposed to radiolabelled 24179, binding determined by gamma spectrometry.
Curated By
- BioGRID