BAIT
CALM1
CaMI, rCG_20808
calmodulin 1
GO Process (21)
GO Function (19)
GO Component (14)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [ISO]
- activation of adenylate cyclase activity [IDA]
- calcium-mediated signaling [IMP]
- detection of calcium ion [ISO]
- positive regulation of DNA binding [ISO]
- positive regulation of cyclic nucleotide metabolic process [ISO]
- positive regulation of cyclic-nucleotide phosphodiesterase activity [ISO]
- positive regulation of nitric-oxide synthase activity [IDA]
- positive regulation of phosphoprotein phosphatase activity [ISO]
- positive regulation of protein dephosphorylation [ISO]
- positive regulation of ryanodine-sensitive calcium-release channel activity [ISO]
- regulation of cardiac muscle contraction [ISO]
- regulation of cytokinesis [ISO]
- regulation of heart rate [ISO]
- regulation of high voltage-gated calcium channel activity [IMP]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [ISO]
- regulation of ryanodine-sensitive calcium-release channel activity [IDA]
- regulation of store-operated calcium channel activity [IC]
- response to amphetamine [IEP]
- response to calcium ion [ISO]
- substantia nigra development [ISO]
Gene Ontology Molecular Function- N-terminal myristoylation domain binding [ISO]
- adenylate cyclase binding [IDA]
- calcium channel regulator activity [NAS]
- calcium ion binding [IDA, ISO]
- calcium-dependent protein binding [IPI]
- enzyme regulator activity [IMP]
- ion channel binding [IDA, ISO]
- nitric-oxide synthase binding [IDA]
- nitric-oxide synthase regulator activity [IDA]
- phosphatidylinositol 3-kinase binding [IPI]
- phospholipase binding [ISO]
- protein N-terminus binding [IMP]
- protein binding [IPI]
- protein domain specific binding [IPI, ISO]
- protein kinase binding [ISO]
- protein phosphatase activator activity [ISO]
- thioesterase binding [ISO]
- titin binding [ISO]
- type 3 metabotropic glutamate receptor binding [IPI]
- N-terminal myristoylation domain binding [ISO]
- adenylate cyclase binding [IDA]
- calcium channel regulator activity [NAS]
- calcium ion binding [IDA, ISO]
- calcium-dependent protein binding [IPI]
- enzyme regulator activity [IMP]
- ion channel binding [IDA, ISO]
- nitric-oxide synthase binding [IDA]
- nitric-oxide synthase regulator activity [IDA]
- phosphatidylinositol 3-kinase binding [IPI]
- phospholipase binding [ISO]
- protein N-terminus binding [IMP]
- protein binding [IPI]
- protein domain specific binding [IPI, ISO]
- protein kinase binding [ISO]
- protein phosphatase activator activity [ISO]
- thioesterase binding [ISO]
- titin binding [ISO]
- type 3 metabotropic glutamate receptor binding [IPI]
Gene Ontology Cellular Component
Rattus norvegicus
PREY
PFKM
ATP-PFK, PFK-A, Pfk-M
phosphofructokinase, muscle
GO Process (10)
GO Function (11)
GO Component (5)
Gene Ontology Biological Process
- carbohydrate phosphorylation [IDA, IMP, ISO, ISS, NAS]
- cellular glucose homeostasis [NAS]
- fructose 1,6-bisphosphate metabolic process [IDA]
- fructose 6-phosphate metabolic process [IDA, ISO]
- glucose homeostasis [ISO]
- glycolytic process [IDA, ISO]
- muscle cell cellular homeostasis [ISO]
- positive regulation of insulin secretion [ISO]
- protein homotetramerization [IDA]
- protein oligomerization [ISO]
Gene Ontology Molecular Function- 6-phosphofructokinase activity [IDA, ISO, ISS]
- AMP binding [IDA]
- ATP binding [IDA, ISO]
- carbohydrate binding [IDA]
- fructose binding [ISO]
- fructose-6-phosphate binding [IDA]
- identical protein binding [ISO]
- kinase binding [ISO]
- phosphofructokinase activity [IMP, ISO, NAS]
- protein C-terminus binding [ISO]
- protein homodimerization activity [ISO]
- 6-phosphofructokinase activity [IDA, ISO, ISS]
- AMP binding [IDA]
- ATP binding [IDA, ISO]
- carbohydrate binding [IDA]
- fructose binding [ISO]
- fructose-6-phosphate binding [IDA]
- identical protein binding [ISO]
- kinase binding [ISO]
- phosphofructokinase activity [IMP, ISO, NAS]
- protein C-terminus binding [ISO]
- protein homodimerization activity [ISO]
Gene Ontology Cellular Component
Rattus norvegicus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Identification and characterization of wolframin, the product of the wolfram syndrome gene (WFS1), as a novel calmodulin-binding protein.
To search for calmodulin (CaM) targets, we performed affinity chromatography purification of a rat brain extract using CaM fused with GST as the affinity ligand. Proteomic analysis was then carried out to identify CaM-binding proteins. In addition to identifying 36 known CaM-binding proteins, including CaM kinases, calcineurin, nNOS, the IP(3) receptor, and Ca(2+)-ATPase, we identified an ER transmembrane protein, wolframin ... [more]
Biochemistry May. 12, 2009; 48(18);3946-55 [Pubmed: 19292454]
Throughput
- High Throughput
Curated By
- BioGRID