CALM1
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [ISO]
- activation of adenylate cyclase activity [IDA]
- calcium-mediated signaling [IMP]
- detection of calcium ion [ISO]
- positive regulation of DNA binding [ISO]
- positive regulation of cyclic nucleotide metabolic process [ISO]
- positive regulation of cyclic-nucleotide phosphodiesterase activity [ISO]
- positive regulation of nitric-oxide synthase activity [IDA]
- positive regulation of phosphoprotein phosphatase activity [ISO]
- positive regulation of protein dephosphorylation [ISO]
- positive regulation of ryanodine-sensitive calcium-release channel activity [ISO]
- regulation of cardiac muscle contraction [ISO]
- regulation of cytokinesis [ISO]
- regulation of heart rate [ISO]
- regulation of high voltage-gated calcium channel activity [IMP]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [ISO]
- regulation of ryanodine-sensitive calcium-release channel activity [IDA]
- regulation of store-operated calcium channel activity [IC]
- response to amphetamine [IEP]
- response to calcium ion [ISO]
- substantia nigra development [ISO]
Gene Ontology Molecular Function- N-terminal myristoylation domain binding [ISO]
- adenylate cyclase binding [IDA]
- calcium channel regulator activity [NAS]
- calcium ion binding [IDA, ISO]
- calcium-dependent protein binding [IPI]
- enzyme regulator activity [IMP]
- ion channel binding [IDA, ISO]
- nitric-oxide synthase binding [IDA]
- nitric-oxide synthase regulator activity [IDA]
- phosphatidylinositol 3-kinase binding [IPI]
- phospholipase binding [ISO]
- protein N-terminus binding [IMP]
- protein binding [IPI]
- protein domain specific binding [IPI, ISO]
- protein kinase binding [ISO]
- protein phosphatase activator activity [ISO]
- thioesterase binding [ISO]
- titin binding [ISO]
- type 3 metabotropic glutamate receptor binding [IPI]
- N-terminal myristoylation domain binding [ISO]
- adenylate cyclase binding [IDA]
- calcium channel regulator activity [NAS]
- calcium ion binding [IDA, ISO]
- calcium-dependent protein binding [IPI]
- enzyme regulator activity [IMP]
- ion channel binding [IDA, ISO]
- nitric-oxide synthase binding [IDA]
- nitric-oxide synthase regulator activity [IDA]
- phosphatidylinositol 3-kinase binding [IPI]
- phospholipase binding [ISO]
- protein N-terminus binding [IMP]
- protein binding [IPI]
- protein domain specific binding [IPI, ISO]
- protein kinase binding [ISO]
- protein phosphatase activator activity [ISO]
- thioesterase binding [ISO]
- titin binding [ISO]
- type 3 metabotropic glutamate receptor binding [IPI]
Gene Ontology Cellular Component
AKAP5
Gene Ontology Biological Process
- cellular protein complex disassembly [IDA]
- cellular response to organonitrogen compound [IEP]
- hippocampus development [IEP]
- maternal process involved in female pregnancy [IEP]
- negative regulation of adenylate cyclase activity [IDA]
- negative regulation of ion transport [IMP]
- negative regulation of potassium ion transport [IMP]
- positive regulation of NFAT protein import into nucleus [IMP]
- positive regulation of adenylate cyclase activity [IDA]
- positive regulation of cAMP biosynthetic process [ISO]
- positive regulation of calcium ion transport into cytosol [IDA]
- positive regulation of dendrite morphogenesis [IMP]
- positive regulation of protein kinase A signaling [ISO]
- positive regulation of protein phosphorylation [IMP]
- response to electrical stimulus [IEP]
- response to muscle activity [IEP]
- spinal cord development [IEP]
Gene Ontology Molecular Function- G-protein coupled receptor binding [IPI]
- GABA receptor binding [IDA]
- actin binding [IDA]
- adenylate cyclase binding [IDA, ISO]
- cadherin binding [IPI]
- kinase binding [IDA]
- protein binding [IPI]
- protein complex binding [IDA, IPI]
- protein domain specific binding [IDA, IPI]
- protein kinase A regulatory subunit binding [IDA]
- protein kinase binding [IDA, IPI]
- protein phosphatase 2B binding [IDA]
- G-protein coupled receptor binding [IPI]
- GABA receptor binding [IDA]
- actin binding [IDA]
- adenylate cyclase binding [IDA, ISO]
- cadherin binding [IPI]
- kinase binding [IDA]
- protein binding [IPI]
- protein complex binding [IDA, IPI]
- protein domain specific binding [IDA, IPI]
- protein kinase A regulatory subunit binding [IDA]
- protein kinase binding [IDA, IPI]
- protein phosphatase 2B binding [IDA]
Gene Ontology Cellular Component
- asymmetric synapse [IDA]
- basolateral plasma membrane [IDA]
- cytoplasm [IDA]
- dendrite membrane [IDA]
- dendritic shaft [IDA]
- dendritic spine [IDA]
- dendritic spine membrane [IDA]
- filopodium membrane [IDA]
- neuronal cell body [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, TAS]
- postsynaptic density [IDA]
- protein complex [IDA]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Identification and characterization of wolframin, the product of the wolfram syndrome gene (WFS1), as a novel calmodulin-binding protein.
To search for calmodulin (CaM) targets, we performed affinity chromatography purification of a rat brain extract using CaM fused with GST as the affinity ligand. Proteomic analysis was then carried out to identify CaM-binding proteins. In addition to identifying 36 known CaM-binding proteins, including CaM kinases, calcineurin, nNOS, the IP(3) receptor, and Ca(2+)-ATPase, we identified an ER transmembrane protein, wolframin ... [more]
Throughput
- High Throughput
Curated By
- BioGRID