BAIT
FOXA1
HNF3A, TCF3A
forkhead box A1
GO Process (9)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- chromatin remodeling [ISS]
- negative regulation of epithelial to mesenchymal transition [IMP]
- positive regulation of cell-cell adhesion mediated by cadherin [IC]
- positive regulation of intracellular estrogen receptor signaling pathway [IMP]
- positive regulation of mitotic cell cycle [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- response to estradiol [IDA]
- transcription from RNA polymerase II promoter [IBA]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISS]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IBA]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription regulatory region DNA binding [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISS]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IBA]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription regulatory region DNA binding [IDA]
Homo sapiens
PREY
GSTM3
GST5, GSTB, GSTM3-3, GTM3, RP4-735C1.2
glutathione S-transferase mu 3 (brain)
GO Process (9)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- cellular detoxification of nitrogen compound [IDA]
- establishment of blood-nerve barrier [TAS]
- glutathione derivative biosynthetic process [TAS]
- glutathione metabolic process [IDA]
- nitrobenzene metabolic process [IDA]
- response to estrogen [IEP]
- small molecule metabolic process [TAS]
- xenobiotic catabolic process [IDA]
- xenobiotic metabolic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3.
FOXA1 is a pioneer factor that binds to enhancer regions that are enriched in H3K4 mono- and dimethylation (H3K4me1 and H3K4me2). We performed a FOXA1 rapid immunoprecipitation mass spectrometry of endogenous proteins (RIME) screen in ERα-positive MCF-7 breast cancer cells and found histone-lysine N-methyltransferase (MLL3) as the top FOXA1-interacting protein. MLL3 is typically thought to induce H3K4me3 at promoter regions, ... [more]
Cell Rep Dec. 06, 2015; 17(10);2715-2723 [Pubmed: 27926873]
Throughput
- High Throughput
Curated By
- BioGRID