BAIT
TRIM25
EFP, RNF147, Z147, ZNF147
tripartite motif containing 25
GO Process (7)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- innate immune response [IDA, TAS]
- negative regulation of type I interferon production [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- regulation of viral entry into host cell [IDA]
- regulation of viral release from host cell [IMP]
Gene Ontology Molecular Function
Homo sapiens
PREY
RAB3GAP2
RAB3-GAP150, RAB3GAP150, SPG69, WARBM2, p150, RP11-568G11.1
RAB3 GTPase activating protein subunit 2 (non-catalytic)
GO Process (7)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- establishment of protein localization to endoplasmic reticulum membrane [IMP]
- intracellular protein transport [TAS]
- positive regulation of GTPase activity [TAS]
- positive regulation of Rab GTPase activity [IMP]
- positive regulation of catalytic activity [TAS]
- positive regulation of endoplasmic reticulum tubular network organization [IMP]
- regulation of GTPase activity [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination.
TRIM25 is a novel RNA-binding protein and a member of the Tripartite Motif (TRIM) family of E3 ubiquitin ligases, which plays a pivotal role in the innate immune response. However, there is scarce knowledge about its RNA-related roles in cell biology. Furthermore, its RNA-binding domain has not been characterized.Here, we reveal that the RNA-binding activity of TRIM25 is mediated by ... [more]
BMC Biol. Nov. 08, 2017; 15(1);105 [Pubmed: 29117863]
Throughput
- High Throughput
Curated By
- BioGRID