BAIT
TRIM25
EFP, RNF147, Z147, ZNF147
tripartite motif containing 25
GO Process (7)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- innate immune response [IDA, TAS]
- negative regulation of type I interferon production [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- regulation of viral entry into host cell [IDA]
- regulation of viral release from host cell [IMP]
Gene Ontology Molecular Function
Homo sapiens
PREY
RAPGEF2
CNrasGEF, NRAPGEP, PDZ-GEF1, PDZGEF1, RA-GEF, RA-GEF-1, Rap-GEP, nRap GEP
Rap guanine nucleotide exchange factor (GEF) 2
GO Process (35)
GO Function (12)
GO Component (11)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- MAPK cascade [NAS]
- Rap protein signal transduction [IMP]
- adenylate cyclase-activating adrenergic receptor signaling pathway [IDA]
- blood vessel development [ISS]
- brain-derived neurotrophic factor receptor signaling pathway [ISS]
- cAMP-mediated signaling [IDA, NAS]
- cellular response to cAMP [IDA]
- cellular response to cGMP [IDA]
- cellular response to nerve growth factor stimulus [ISS]
- establishment of endothelial barrier [IMP]
- forebrain neuron development [ISS]
- intracellular signal transduction [TAS]
- negative regulation of cell proliferation [IDA]
- negative regulation of dendrite morphogenesis [IDA]
- negative regulation of melanin biosynthetic process [ISS]
- nerve growth factor signaling pathway [ISS]
- neuron migration [ISS]
- neuron projection development [IDA]
- neuropeptide signaling pathway [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of Rap GTPase activity [IDA, IMP]
- positive regulation of Ras GTPase activity [IDA]
- positive regulation of cAMP-dependent protein kinase activity [IDA]
- positive regulation of cAMP-mediated signaling [IDA]
- positive regulation of dendritic cell apoptotic process [IDA]
- positive regulation of neuron migration [ISS]
- positive regulation of neuron projection development [ISS]
- positive regulation of protein binding [ISS]
- positive regulation of protein kinase activity [IDA]
- positive regulation of vasculogenesis [ISS]
- regulation of cell junction assembly [IMP]
- regulation of synaptic plasticity [ISS]
- small GTPase mediated signal transduction [TAS]
- ventricular system development [ISS]
Gene Ontology Molecular Function- PDZ domain binding [IDA]
- Rap GTPase activator activity [IDA]
- Rap guanyl-nucleotide exchange factor activity [IDA, IMP]
- Ras guanyl-nucleotide exchange factor activity [IDA]
- WW domain binding [IDA]
- beta-1 adrenergic receptor binding [IDA]
- cAMP binding [IDA]
- cGMP binding [IDA]
- calcium ion binding [NAS]
- diacylglycerol binding [NAS]
- protein binding [IPI]
- signal transducer activity [TAS]
- PDZ domain binding [IDA]
- Rap GTPase activator activity [IDA]
- Rap guanyl-nucleotide exchange factor activity [IDA, IMP]
- Ras guanyl-nucleotide exchange factor activity [IDA]
- WW domain binding [IDA]
- beta-1 adrenergic receptor binding [IDA]
- cAMP binding [IDA]
- cGMP binding [IDA]
- calcium ion binding [NAS]
- diacylglycerol binding [NAS]
- protein binding [IPI]
- signal transducer activity [TAS]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination.
TRIM25 is a novel RNA-binding protein and a member of the Tripartite Motif (TRIM) family of E3 ubiquitin ligases, which plays a pivotal role in the innate immune response. However, there is scarce knowledge about its RNA-related roles in cell biology. Furthermore, its RNA-binding domain has not been characterized.Here, we reveal that the RNA-binding activity of TRIM25 is mediated by ... [more]
BMC Biol. Nov. 08, 2017; 15(1);105 [Pubmed: 29117863]
Throughput
- High Throughput
Curated By
- BioGRID