SHP1
Gene Ontology Biological Process
- ER-associated ubiquitin-dependent protein catabolic process [IMP]
- ascospore formation [IMP]
- autophagic vacuole assembly [IMP]
- glycogen metabolic process [IMP]
- piecemeal microautophagy of nucleus [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- sister chromatid biorientation [IMP]
Gene Ontology Molecular Function
SRP54
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Assembly and quality control of the protein phosphatase 1 holoenzyme involves the Cdc48-Shp1 chaperone.
Protein phosphatase 1 (PP1) controls many aspects of cell physiology, which depends on its correct targeting in the cell. Nuclear localization of Glc7, the catalytic subunit of PP1 in budding yeast, requires the AAA-ATPase Cdc48 and its adaptor Shp1 through an unknown mechanism. Herein, we show that mutations in SHP1 cause misfolding of Glc7 that co-aggregates with Hsp104 and Hsp42 ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SHP1 SRP54 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1892 | BioGRID | 2027489 |
Curated By
- BioGRID