BAIT
CD22
A530093D23, Lyb-8, Lyb8
CD22 antigen
GO Process (1)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SYK
Sykb
spleen tyrosine kinase
GO Process (52)
GO Function (11)
GO Component (9)
Gene Ontology Biological Process
- B cell receptor signaling pathway [IDA]
- G-protein coupled receptor signaling pathway [TAS]
- activation of JUN kinase activity [IMP]
- activation of MAPK activity [IDA, IMP]
- adaptive immune response [IBA]
- beta selection [IGI]
- blood vessel morphogenesis [IMP]
- cell migration [IBA]
- cell surface receptor signaling pathway [IDA, IMP]
- cellular response to molecule of fungal origin [IMP]
- defense response to bacterium [IMP]
- enzyme linked receptor protein signaling pathway [IDA]
- innate immune response [IMP]
- integrin-mediated signaling pathway [IMP]
- intracellular signal transduction [IDA, IMP]
- leukocyte activation involved in immune response [IMP]
- leukocyte cell-cell adhesion [ISO]
- leukotriene biosynthetic process [IMP]
- lymph vessel development [IMP]
- macrophage activation involved in immune response [IMP]
- neutrophil activation involved in immune response [IMP]
- neutrophil chemotaxis [ISO]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA, IMP, ISO]
- positive regulation of B cell differentiation [IMP]
- positive regulation of alpha-beta T cell differentiation [IGI]
- positive regulation of alpha-beta T cell proliferation [IGI]
- positive regulation of bone resorption [IMP]
- positive regulation of calcium-mediated signaling [IMP]
- positive regulation of cell adhesion mediated by integrin [IMP]
- positive regulation of cytokine secretion [IGI]
- positive regulation of gamma-delta T cell differentiation [IMP]
- positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process [IMP]
- positive regulation of interleukin-3 biosynthetic process [IMP]
- positive regulation of mast cell degranulation [IMP, ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP]
- protein autophosphorylation [IDA, ISO]
- regulation of ERK1 and ERK2 cascade [IMP]
- regulation of arachidonic acid secretion [IMP]
- regulation of immune response [ISO]
- regulation of neutrophil degranulation [IMP]
- regulation of phagocytosis [IMP]
- regulation of platelet activation [IMP]
- regulation of platelet aggregation [IMP]
- regulation of sequence-specific DNA binding transcription factor activity [ISO]
- regulation of superoxide anion generation [IMP]
- serotonin secretion [IMP]
- serotonin secretion by platelet [IMP]
- signal transduction by phosphorylation [IDA]
- transcription factor import into nucleus [ISO]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function- ATP binding [IDA]
- integrin binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IDA, ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase activity [ISO]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [ISO]
- protein tyrosine kinase activity [IDA, IMP, ISO]
- receptor binding [IBA]
- receptor signaling protein tyrosine kinase activity [IDA]
- ATP binding [IDA]
- integrin binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IDA, ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase activity [ISO]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [ISO]
- protein tyrosine kinase activity [IDA, IMP, ISO]
- receptor binding [IBA]
- receptor signaling protein tyrosine kinase activity [IDA]
Gene Ontology Cellular Component
Mus musculus
Far Western
An interaction is detected between a protein immobilized on a membrane and a purified protein probe.
Publication
Analysis of tyrosine phosphorylation-dependent interactions between stimulatory effector proteins and the B cell co-receptor CD22.
The B cell-restricted transmembrane glycoprotein CD22 is rapidly phosphorylated on tyrosine in response to cross-linking of the B cell antigen receptor, thereby generating phosphotyrosine motifs in the cytoplasmic domain which recruit intracellular effector proteins that contain Src homology 2 domains. By virtue of its interaction with these effector proteins CD22 modulates signal transduction through the B cell antigen receptor. To ... [more]
J. Biol. Chem. Jun. 25, 1999; 274(26);18769-76 [Pubmed: 10373493]
Throughput
- Low Throughput
Related interactions
Curated By
- BioGRID