BAIT
CDKN2A
ARF, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16
cyclin-dependent kinase inhibitor 2A
GO Process (37)
GO Function (9)
GO Component (8)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IDA]
- Ras protein signal transduction [IEP]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- apoptotic mitochondrial changes [IMP]
- cell cycle arrest [IDA, IMP]
- cellular senescence [IMP]
- mitotic cell cycle [TAS]
- negative regulation of B cell proliferation [ISS]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of cell growth [IDA]
- negative regulation of cell proliferation [IDA, IMP]
- negative regulation of cell-matrix adhesion [IMP]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- negative regulation of immature T cell proliferation in thymus [ISS]
- negative regulation of phosphorylation [IDA]
- negative regulation of protein kinase activity [IMP]
- negative regulation of transcription, DNA-templated [IMP]
- negative regulation of ubiquitin-protein transferase activity [ISS]
- positive regulation of DNA damage response, signal transduction by p53 class mediator [IDA]
- positive regulation of cell cycle arrest [IDA]
- positive regulation of cellular senescence [IMP]
- positive regulation of macrophage apoptotic process [ISS]
- positive regulation of protein sumoylation [IMP]
- positive regulation of smooth muscle cell apoptotic process [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein K63-linked ubiquitination [IDA]
- protein destabilization [IDA]
- protein polyubiquitination [IDA]
- protein stabilization [IDA]
- regulation of G2/M transition of mitotic cell cycle [IMP]
- regulation of apoptotic DNA fragmentation [IMP]
- regulation of protein export from nucleus [IMP]
- regulation of protein stability [ISS]
- replicative senescence [IMP]
- senescence-associated heterochromatin focus assembly [IMP]
- somatic stem cell division [ISS]
Gene Ontology Molecular Function- MDM2/MDM4 family protein binding [IPI]
- NF-kappaB binding [IDA]
- cyclin-dependent protein serine/threonine kinase inhibitor activity [IDA]
- p53 binding [IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein kinase binding [IPI]
- transcription factor binding [IPI]
- ubiquitin-protein transferase inhibitor activity [ISS]
- MDM2/MDM4 family protein binding [IPI]
- NF-kappaB binding [IDA]
- cyclin-dependent protein serine/threonine kinase inhibitor activity [IDA]
- p53 binding [IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein kinase binding [IPI]
- transcription factor binding [IPI]
- ubiquitin-protein transferase inhibitor activity [ISS]
Gene Ontology Cellular Component
Homo sapiens
PREY
ANKRA2
ANKRA
ankyrin repeat, family A (RFXANK-like), 2
GO Process (1)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor.
Perturbed genotypes in cancer can now be identified by whole genome sequencing of large number of diverse tumor samples, and observed gene mutations can be used for prognosis and classification of cancer subtypes. Although mutations in a few causative genes are directly linked to key signaling pathways perturbation, a global understanding of how known cancer genes drive oncogenesis in human ... [more]
BMC Cancer Dec. 26, 2015; 16();335 [Pubmed: 27229929]
Throughput
- High Throughput
Curated By
- BioGRID