BAIT
SMARCB1
BAF47, INI1, MRD15, PPP1R144, RDT, RTPS1, SNF5, SNF5L1, SWNTS1, Sfh1p, Snr1, hSNFS
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
GO Process (13)
GO Function (7)
GO Component (8)
Gene Ontology Biological Process
- ATP-dependent chromatin remodeling [IBA, IDA]
- DNA integration [TAS]
- DNA repair [IBA]
- cell differentiation [IBA]
- chromatin remodeling [IDA]
- mitotic cell cycle phase transition [IBA]
- negative regulation of cell proliferation [IBA]
- nucleosome disassembly [IDA]
- positive regulation by host of viral transcription [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription from RNA polymerase II promoter [NAS]
- single stranded viral RNA replication via double stranded DNA intermediate [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NCK2
GRB4, NCKbeta
NCK adaptor protein 2
GO Process (10)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- T cell activation [NAS]
- axon guidance [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- negative regulation of cell proliferation [TAS]
- positive regulation of T cell proliferation [IMP]
- positive regulation of actin filament polymerization [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of epidermal growth factor-activated receptor activity [TAS]
- signal complex assembly [NAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor.
Perturbed genotypes in cancer can now be identified by whole genome sequencing of large number of diverse tumor samples, and observed gene mutations can be used for prognosis and classification of cancer subtypes. Although mutations in a few causative genes are directly linked to key signaling pathways perturbation, a global understanding of how known cancer genes drive oncogenesis in human ... [more]
BMC Cancer Dec. 26, 2015; 16();335 [Pubmed: 27229929]
Throughput
- High Throughput
Curated By
- BioGRID