VPS21
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
APM3
Gene Ontology Biological Process
Gene Ontology Cellular Component
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Bifurcation of the endocytic pathway into Rab5-dependent and -independent transport to the vacuole.
The yeast Rab5 homologue, Vps21p, is known to be involved both in the vacuolar protein sorting (VPS) pathway from the trans-Golgi network to the vacuole, and in the endocytic pathway from the plasma membrane to the vacuole. However, the intracellular location at which these two pathways converge remains unclear. In addition, the endocytic pathway is not completely blocked in yeast ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: protein transport (APO:0000129)
Additional Notes
- alpha-factor transport
- genetic complex
- vps21 ypt52 ypt53 apm3 quadruple mutant
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
APM3 VPS21 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 163660 |
Curated By
- BioGRID