DRD1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [ISO]
- activation of adenylate cyclase activity [IDA, ISO]
- adenylate cyclase-activating G-protein coupled receptor signaling pathway [ISO]
- adenylate cyclase-activating dopamine receptor signaling pathway [IDA, ISO]
- adult walking behavior [ISO]
- associative learning [IEP, IMP, ISO]
- astrocyte development [ISO]
- behavioral fear response [ISO]
- behavioral response to cocaine [IMP, ISO]
- calcium-mediated signaling [IDA]
- cellular response to catecholamine stimulus [ISO]
- cellular response to hypoxia [IEP]
- cellular response to insulin stimulus [IEP]
- cerebral cortex GABAergic interneuron migration [ISO]
- conditioned taste aversion [ISO]
- dentate gyrus development [ISO]
- dopamine receptor signaling pathway [IDA, IMP, ISO, TAS]
- dopamine transport [ISO]
- feeding behavior [ISO]
- glucose import [ISO]
- grooming behavior [ISO]
- habituation [ISO]
- hippocampus development [ISO]
- intracellular protein transport [IMP]
- learning [ISO]
- locomotory behavior [IMP, ISO]
- long term synaptic depression [ISO]
- long-term synaptic potentiation [ISO]
- maternal behavior [ISO]
- mating behavior [ISO]
- memory [ISO]
- muscle contraction [ISO]
- negative regulation of cell migration [IMP]
- negative regulation of circadian sleep/wake cycle, sleep [IDA]
- negative regulation of protein kinase activity [IMP]
- neuronal action potential [ISO]
- operant conditioning [IMP, ISO]
- orbitofrontal cortex development [IEP]
- peristalsis [ISO]
- phosphatidylinositol catabolic process [IDA]
- phosphatidylinositol metabolic process [IDA]
- phospholipase C-activating dopamine receptor signaling pathway [ISO]
- positive regulation of adenylate cyclase activity [IDA]
- positive regulation of cAMP biosynthetic process [IDA, IMP, ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [ISO]
- positive regulation of feeding behavior [IMP]
- positive regulation of long-term synaptic potentiation [IMP]
- positive regulation of membrane potential [IMP]
- positive regulation of release of sequestered calcium ion into cytosol [ISO]
- positive regulation of synaptic transmission, glutamatergic [ISO]
- prepulse inhibition [ISO]
- protein import into nucleus [ISO]
- regulation of dopamine metabolic process [ISO]
- regulation of ion transport [IDA]
- regulation of long-term neuronal synaptic plasticity [IMP]
- regulation of vasoconstriction [IMP]
- response to activity [IEP]
- response to amino acid [IEP]
- response to amphetamine [IEP, ISO]
- response to antidepressant [IEP]
- response to cocaine [ISO]
- response to drug [IEP, ISO]
- response to estradiol [IEP]
- response to ethanol [IEP]
- response to food [IEP]
- response to morphine [IEP]
- response to nicotine [IEP]
- response to organic cyclic compound [IEP]
- response to organonitrogen compound [IEP]
- response to retinoic acid [IEP]
- response to steroid hormone [IEP]
- sensitization [ISO]
- social behavior [IMP]
- startle response [ISO]
- striatum development [IEP, ISO]
- synapse assembly [IEP]
- synaptic transmission [ISO]
- synaptic transmission, dopaminergic [IDA, IMP, ISO]
- temperature homeostasis [ISO]
- transmission of nerve impulse [ISO]
- visual learning [IMP, ISO]
Gene Ontology Molecular Function- ATPase binding [IPI]
- D3 dopamine receptor binding [IPI]
- G-protein alpha-subunit binding [IPI]
- G-protein coupled receptor activity [IDA, ISO]
- angiotensin receptor binding [IPI]
- dopamine binding [ISO]
- dopamine neurotransmitter receptor activity [ISO]
- dopamine neurotransmitter receptor activity, coupled via Gs [IDA, IMP, ISO]
- drug binding [IDA]
- protein binding [IPI]
- protein complex binding [IPI]
- protein heterodimerization activity [IPI]
- protein phosphatase binding [IPI]
- receptor binding [IPI]
- ATPase binding [IPI]
- D3 dopamine receptor binding [IPI]
- G-protein alpha-subunit binding [IPI]
- G-protein coupled receptor activity [IDA, ISO]
- angiotensin receptor binding [IPI]
- dopamine binding [ISO]
- dopamine neurotransmitter receptor activity [ISO]
- dopamine neurotransmitter receptor activity, coupled via Gs [IDA, IMP, ISO]
- drug binding [IDA]
- protein binding [IPI]
- protein complex binding [IPI]
- protein heterodimerization activity [IPI]
- protein phosphatase binding [IPI]
- receptor binding [IPI]
Gene Ontology Cellular Component
- axon [IDA]
- axon terminus [IDA]
- caveola [IDA]
- cell [ISO]
- dendrite [IDA]
- dendritic shaft [IDA]
- dendritic spine [IDA]
- dendritic spine head [IDA]
- dendritic spine neck [IDA]
- endoplasmic reticulum [IDA]
- integral component of membrane [IDA]
- intracellular [ISO]
- membrane [ISO]
- neuronal cell body [IDA]
- nucleus [ISO]
- plasma membrane [IDA, ISO]
AGTR1A
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IMP, ISO]
- Rho protein signal transduction [ISO]
- activation of Janus kinase activity [IMP]
- aging [IEP]
- angiotensin-activated signaling pathway [ISO]
- blood vessel development [ISO]
- brain renin-angiotensin system [ISO]
- calcium-mediated signaling [ISO]
- cell chemotaxis [ISO]
- cellular response to dexamethasone stimulus [IDA]
- dopamine biosynthetic process [IMP]
- drinking behavior [IMP, ISO]
- heart development [ISO]
- inflammatory response [ISO]
- kidney development [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of smooth muscle cell apoptotic process [ISO]
- phospholipase C-activating G-protein coupled receptor signaling pathway [IDA]
- phospholipase C-activating angiotensin-activated signaling pathway [IDA, IMP, ISO]
- positive regulation of blood pressure [IMP, ISO]
- positive regulation of branching involved in ureteric bud morphogenesis [IMP]
- positive regulation of cell proliferation [IMP, ISO]
- positive regulation of cellular protein metabolic process [ISO]
- positive regulation of cholesterol esterification [ISO]
- positive regulation of cytokine secretion [ISO]
- positive regulation of cytosolic calcium ion concentration [IDA, ISO]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [ISO]
- positive regulation of phospholipase A2 activity [ISO]
- positive regulation of receptor recycling [IDA]
- positive regulation of superoxide anion generation [IMP]
- regulation of blood pressure [TAS]
- regulation of pH [IDA]
- regulation of renal output by angiotensin [ISO]
- regulation of smooth muscle cell apoptotic process [ISO]
- regulation of systemic arterial blood pressure by circulatory renin-angiotensin [ISO]
- regulation of vasoconstriction [ISO]
- renin secretion into blood stream [ISO]
- renin-angiotensin regulation of aldosterone production [IMP, ISO]
- response to estrogen [IDA, IEP]
- vasoconstriction [IMP]
Gene Ontology Molecular Function- D1 dopamine receptor binding [IPI]
- G-protein alpha-subunit binding [IMP]
- angiotensin type I receptor activity [IDA, IMP, ISO]
- angiotensin type II receptor activity [ISO]
- bradykinin receptor binding [ISO]
- peptide hormone binding [IMP]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein kinase binding [IPI]
- protein self-association [IMP]
- D1 dopamine receptor binding [IPI]
- G-protein alpha-subunit binding [IMP]
- angiotensin type I receptor activity [IDA, IMP, ISO]
- angiotensin type II receptor activity [ISO]
- bradykinin receptor binding [ISO]
- peptide hormone binding [IMP]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein kinase binding [IPI]
- protein self-association [IMP]
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- basolateral plasma membrane [IDA]
- cell [ISO]
- cytoplasm [ISO]
- cytoplasmic vesicle [IDA]
- dendrite [IDA]
- endomembrane system [IDA]
- endosome [ISO]
- integral component of membrane [TAS]
- membrane [IDA]
- organelle outer membrane [IDA]
- plasma membrane [IDA, ISO]
- recycling endosome [IDA]
- vesicle lumen [IDA]
- vesicle membrane [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Binding of losartan to angiotensin AT1 receptors increases dopamine D1 receptor activation.
Signaling through both angiotensin AT1 receptors (AT1R) and dopamine D1 receptors (D1R) modulates renal sodium excretion and arterial BP. AT1R and D1R form heterodimers, but whether treatment with AT1R antagonists functionally modifies D1R via allosterism is unknown. In this study, the AT1R antagonist losartan strengthened the interaction between AT1R and D1R and increased expression of D1R on the plasma membrane ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| AGTR1A DRD1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| AGTR1A DRD1 | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | 2381411 |
Curated By
- BioGRID