BAIT
UBE2A
HHR6A, MRXS30, MRXSN, RAD6A, UBC2
ubiquitin-conjugating enzyme E2A
GO Process (12)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- DNA repair [IGI]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- histone H2A ubiquitination [IDA]
- positive regulation of cell proliferation [IDA]
- postreplication repair [NAS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein K11-linked ubiquitination [IDA]
- protein K48-linked ubiquitination [IDA]
- protein autoubiquitination [IDA]
- protein polyubiquitination [TAS]
- response to UV [IGI]
- ubiquitin-dependent protein catabolic process [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DOCK7
EIEE23, ZIR2, RP4-740B20.2
dedicator of cytokinesis 7
GO Process (8)
GO Function (1)
GO Component (6)
Gene Ontology Biological Process
- activation of Rac GTPase activity [IDA]
- axonogenesis [IMP]
- establishment of neuroblast polarity [IMP]
- interkinetic nuclear migration [ISS]
- microtubule cytoskeleton organization [IMP]
- neuron projection development [IMP]
- positive regulation of peptidyl-serine phosphorylation [IMP]
- regulation of neurogenesis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Interactome Analysis Reveals a Novel Role for RAD6 in the Regulation of Proteasome Activity and Localization in Response to DNA Damage.
RAD6, an E2 ubiquitin-conjugating enzyme, is a key node for determining different DNA damage repair pathways, controlling both the error-prone and the error-free DNA damage repair pathways through differential regulation of the ubiquitination of the proliferating cell nuclear antigen (PCNA) protein. However, whether other pathways are involved in the RAD6-mediated regulation of DNA damage repair is still unclear. To deeply ... [more]
Mol. Cell. Biol. Mar. 15, 2017; 37(6); [Pubmed: 28031328]
Throughput
- High Throughput
Additional Notes
- Source of UBE2A not clear
Curated By
- BioGRID