BAIT
LMNA
CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, PRO1, RP11-54H19.1
lamin A/C
GO Process (14)
GO Function (2)
GO Component (9)
Gene Ontology Biological Process
- activation of signaling protein activity involved in unfolded protein response [TAS]
- apoptotic process [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- cellular protein metabolic process [TAS]
- cellular response to hypoxia [IEP]
- endoplasmic reticulum unfolded protein response [TAS]
- establishment or maintenance of microtubule cytoskeleton polarity [ISS]
- mitotic cell cycle [TAS]
- mitotic nuclear envelope disassembly [TAS]
- mitotic nuclear envelope reassembly [TAS]
- muscle organ development [IMP]
- positive regulation of cell aging [IDA]
- protein localization to nucleus [ISS]
- regulation of cell migration [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
AQP1
AQP-CHIP, CHIP28, CO
aquaporin 1 (Colton blood group)
GO Process (46)
GO Function (12)
GO Component (15)
Gene Ontology Biological Process
- ammonium transmembrane transport [IDA]
- ammonium transport [IDA]
- bicarbonate transport [TAS]
- cGMP biosynthetic process [IDA]
- carbon dioxide transmembrane transport [IDA]
- carbon dioxide transport [IDA]
- cation transmembrane transport [IDA]
- cell volume homeostasis [IMP]
- cellular homeostasis [IDA]
- cellular hyperosmotic response [IMP]
- cellular response to UV [IDA]
- cellular response to cAMP [IDA, IEP]
- cellular response to copper ion [IDA]
- cellular response to dexamethasone stimulus [IDA]
- cellular response to hydrogen peroxide [IDA]
- cellular response to hypoxia [IDA]
- cellular response to inorganic substance [IDA]
- cellular response to mechanical stimulus [IDA]
- cellular response to mercury ion [IDA]
- cellular response to nitric oxide [IDA]
- cellular response to retinoic acid [IDA]
- cellular response to salt stress [IDA]
- cellular response to stress [IDA]
- cellular water homeostasis [IBA]
- cerebrospinal fluid secretion [IEP]
- establishment or maintenance of actin cytoskeleton polarity [IMP]
- glycerol transport [IDA]
- lateral ventricle development [IEP]
- maintenance of symbiont-containing vacuole by host [IMP]
- multicellular organismal water homeostasis [IEP]
- negative regulation of apoptotic process [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- nitric oxide transport [IDA]
- odontogenesis [IEP]
- pancreatic juice secretion [IEP]
- positive regulation of angiogenesis [IMP]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of saliva secretion [IMP]
- potassium ion transmembrane transport [IMP, ISS]
- potassium ion transport [ISS]
- renal water transport [IDA]
- response to drug [IDA]
- small molecule metabolic process [TAS]
- transepithelial water transport [IDA]
- transmembrane transport [TAS]
- water transport [IDA, IMP, TAS]
Gene Ontology Molecular Function- ammonium transmembrane transporter activity [IDA]
- carbon dioxide transmembrane transporter activity [IDA, TAS]
- glycerol channel activity [IBA]
- glycerol transmembrane transporter activity [IDA]
- intracellular cGMP activated cation channel activity [IDA]
- nitric oxide transmembrane transporter activity [IDA]
- potassium channel activity [IMP]
- potassium ion transmembrane transporter activity [ISS]
- protein binding [IPI]
- transmembrane transporter activity [IDA]
- water channel activity [EXP, IDA, IMP]
- water transmembrane transporter activity [IDA]
- ammonium transmembrane transporter activity [IDA]
- carbon dioxide transmembrane transporter activity [IDA, TAS]
- glycerol channel activity [IBA]
- glycerol transmembrane transporter activity [IDA]
- intracellular cGMP activated cation channel activity [IDA]
- nitric oxide transmembrane transporter activity [IDA]
- potassium channel activity [IMP]
- potassium ion transmembrane transporter activity [ISS]
- protein binding [IPI]
- transmembrane transporter activity [IDA]
- water channel activity [EXP, IDA, IMP]
- water transmembrane transporter activity [IDA]
Gene Ontology Cellular Component
- apical part of cell [IDA]
- apical plasma membrane [IDA]
- basal plasma membrane [IDA]
- basolateral plasma membrane [IDA]
- brush border [IDA]
- brush border membrane [IDA]
- cytoplasm [IDA]
- extracellular vesicular exosome [IDA]
- integral component of plasma membrane [TAS]
- nuclear membrane [IDA]
- nucleus [IDA]
- plasma membrane [IDA, TAS]
- sarcolemma [IDA]
- symbiont-containing vacuole [ISS]
- symbiont-containing vacuole membrane [IDA]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Systematic identification of pathological lamin A interactors.
Laminopathies are a collection of phenotypically diverse diseases that include muscular dystrophies, cardiomyopathies, lipodystrophies, and premature aging syndromes. Laminopathies are caused by >300 distinct mutations in the LMNA gene, which encodes the nuclear intermediate filament proteins lamin A and C, two major architectural elements of the mammalian cell nucleus. The genotype-phenotype relationship and the basis for the pronounced tissue specificity ... [more]
Mol. Biol. Cell May. 01, 2014; 25(9);1493-510 [Pubmed: 24623722]
Throughput
- High Throughput
Curated By
- BioGRID