BAIT
LMNA
CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, PRO1, RP11-54H19.1
lamin A/C
GO Process (14)
GO Function (2)
GO Component (9)
Gene Ontology Biological Process
- activation of signaling protein activity involved in unfolded protein response [TAS]
- apoptotic process [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- cellular protein metabolic process [TAS]
- cellular response to hypoxia [IEP]
- endoplasmic reticulum unfolded protein response [TAS]
- establishment or maintenance of microtubule cytoskeleton polarity [ISS]
- mitotic cell cycle [TAS]
- mitotic nuclear envelope disassembly [TAS]
- mitotic nuclear envelope reassembly [TAS]
- muscle organ development [IMP]
- positive regulation of cell aging [IDA]
- protein localization to nucleus [ISS]
- regulation of cell migration [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
AQP3
AQP-3, GIL
aquaporin 3 (Gill blood group)
GO Process (14)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- carbohydrate transmembrane transport [IBA]
- cellular water homeostasis [IBA]
- excretion [TAS]
- ion transmembrane transport [IBA]
- odontogenesis [IEP]
- positive regulation of immune system process [IDA]
- regulation of keratinocyte differentiation [TAS]
- response to calcium ion [TAS]
- response to retinoic acid [IDA]
- response to vitamin D [TAS]
- transmembrane transport [TAS]
- transport [NAS]
- urea transmembrane transport [IBA]
- water transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Systematic identification of pathological lamin A interactors.
Laminopathies are a collection of phenotypically diverse diseases that include muscular dystrophies, cardiomyopathies, lipodystrophies, and premature aging syndromes. Laminopathies are caused by >300 distinct mutations in the LMNA gene, which encodes the nuclear intermediate filament proteins lamin A and C, two major architectural elements of the mammalian cell nucleus. The genotype-phenotype relationship and the basis for the pronounced tissue specificity ... [more]
Mol. Biol. Cell May. 01, 2014; 25(9);1493-510 [Pubmed: 24623722]
Throughput
- High Throughput
Curated By
- BioGRID