LMNA
Gene Ontology Biological Process
- activation of signaling protein activity involved in unfolded protein response [TAS]
- apoptotic process [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- cellular protein metabolic process [TAS]
- cellular response to hypoxia [IEP]
- endoplasmic reticulum unfolded protein response [TAS]
- establishment or maintenance of microtubule cytoskeleton polarity [ISS]
- mitotic cell cycle [TAS]
- mitotic nuclear envelope disassembly [TAS]
- mitotic nuclear envelope reassembly [TAS]
- muscle organ development [IMP]
- positive regulation of cell aging [IDA]
- protein localization to nucleus [ISS]
- regulation of cell migration [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
F2RL1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- T cell activation involved in immune response [ISS]
- chemokine (C-C motif) ligand 2 secretion [IDA]
- chemokine secretion [IDA]
- defense response to virus [IDA]
- establishment of endothelial barrier [IDA]
- interferon-gamma secretion [ISS]
- interleukin-1 beta secretion [IDA]
- interleukin-10 secretion [IDA]
- leukocyte migration [IDA]
- leukocyte proliferation [ISS]
- mature conventional dendritic cell differentiation [IDA, ISS]
- negative regulation of JNK cascade [IDA]
- negative regulation of chemokine secretion [IDA]
- negative regulation of toll-like receptor 3 signaling pathway [IMP]
- negative regulation of tumor necrosis factor-mediated signaling pathway [IDA]
- neutrophil activation [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA, ISS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of JNK cascade [IDA]
- positive regulation of Rho protein signal transduction [IMP, ISS]
- positive regulation of actin filament depolymerization [IDA]
- positive regulation of cell migration [ISS]
- positive regulation of chemotaxis [ISS]
- positive regulation of cytokine secretion involved in immune response [IDA]
- positive regulation of cytosolic calcium ion concentration [IDA, ISS]
- positive regulation of eosinophil degranulation [IDA]
- positive regulation of glomerular filtration [ISS]
- positive regulation of interleukin-6 secretion [IDA]
- positive regulation of interleukin-8 secretion [IDA]
- positive regulation of leukocyte chemotaxis [IDA]
- positive regulation of neutrophil mediated killing of gram-negative bacterium [IDA]
- positive regulation of phagocytosis, engulfment [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISS]
- positive regulation of positive chemotaxis [IDA]
- positive regulation of pseudopodium assembly [ISS]
- positive regulation of renin secretion into blood stream [ISS]
- positive regulation of superoxide anion generation [IDA]
- positive regulation of toll-like receptor 2 signaling pathway [IMP]
- positive regulation of toll-like receptor 3 signaling pathway [IMP]
- positive regulation of toll-like receptor 4 signaling pathway [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of vasodilation [ISS]
- regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- regulation of JNK cascade [IDA]
- regulation of blood coagulation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Systematic identification of pathological lamin A interactors.
Laminopathies are a collection of phenotypically diverse diseases that include muscular dystrophies, cardiomyopathies, lipodystrophies, and premature aging syndromes. Laminopathies are caused by >300 distinct mutations in the LMNA gene, which encodes the nuclear intermediate filament proteins lamin A and C, two major architectural elements of the mammalian cell nucleus. The genotype-phenotype relationship and the basis for the pronounced tissue specificity ... [more]
Throughput
- High Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
F2RL1 LMNA | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.8878 | BioGRID | 3056592 |
Curated By
- BioGRID