BAIT
LMNA
CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, PRO1, RP11-54H19.1
lamin A/C
GO Process (14)
GO Function (2)
GO Component (9)
Gene Ontology Biological Process
- activation of signaling protein activity involved in unfolded protein response [TAS]
- apoptotic process [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- cellular protein metabolic process [TAS]
- cellular response to hypoxia [IEP]
- endoplasmic reticulum unfolded protein response [TAS]
- establishment or maintenance of microtubule cytoskeleton polarity [ISS]
- mitotic cell cycle [TAS]
- mitotic nuclear envelope disassembly [TAS]
- mitotic nuclear envelope reassembly [TAS]
- muscle organ development [IMP]
- positive regulation of cell aging [IDA]
- protein localization to nucleus [ISS]
- regulation of cell migration [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PKD2
APKD2, PC2, PKD4, Pc-2, TRPP2
polycystic kidney disease 2 (autosomal dominant)
GO Process (48)
GO Function (17)
GO Component (19)
Gene Ontology Biological Process
- JAK-STAT cascade [ISS]
- aorta development [IEP]
- branching involved in ureteric bud morphogenesis [IEP]
- calcium ion transmembrane transport [IDA]
- calcium ion transport [IDA, ISS]
- cell cycle arrest [ISS]
- cellular response to fluid shear stress [IMP]
- cellular response to hydrostatic pressure [IDA]
- cellular response to osmotic stress [IDA]
- cellular response to reactive oxygen species [NAS]
- centrosome duplication [NAS]
- cytoplasmic sequestering of transcription factor [IMP]
- detection of mechanical stimulus [IBA, ISS]
- detection of nodal flow [ISS]
- determination of left/right symmetry [ISS]
- determination of liver left/right asymmetry [IMP]
- embryonic placenta development [ISS]
- heart development [IEP]
- heart looping [IMP]
- liver development [IEP]
- mesonephric duct development [IEP]
- mesonephric tubule development [IEP]
- metanephric S-shaped body morphogenesis [IEP]
- metanephric ascending thin limb development [IEP]
- metanephric cortex development [IEP]
- metanephric cortical collecting duct development [IEP]
- metanephric distal tubule development [IEP]
- metanephric mesenchyme development [IEP]
- metanephric part of ureteric bud development [IEP]
- metanephric smooth muscle tissue development [IEP]
- negative regulation of G1/S transition of mitotic cell cycle [IMP]
- negative regulation of cell proliferation [NAS]
- negative regulation of ryanodine-sensitive calcium-release channel activity [ISS]
- neural tube development [IEP]
- placenta blood vessel development [ISS]
- positive regulation of cell cycle arrest [IMP]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [IDA]
- positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [IMP]
- positive regulation of nitric oxide biosynthetic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- regulation of cAMP metabolic process [ISS]
- regulation of calcium ion import [IDA]
- regulation of cell proliferation [IMP]
- release of sequestered calcium ion into cytosol [IDA, IMP]
- renal artery morphogenesis [IEP]
- renal tubule morphogenesis [ISS]
- sodium ion transmembrane transport [IDA]
- spinal cord development [IEP]
Gene Ontology Molecular Function- ATPase binding [ISS]
- HLH domain binding [IPI]
- actinin binding [IDA]
- calcium ion binding [ISS]
- calcium-induced calcium release activity [IDA]
- cytoskeletal protein binding [IDA]
- identical protein binding [IPI, ISS]
- ion channel binding [IPI]
- phosphoprotein binding [IPI]
- potassium channel activity [ISS]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- receptor binding [IPI]
- voltage-gated calcium channel activity [IDA]
- voltage-gated cation channel activity [IDA]
- voltage-gated ion channel activity [IDA]
- voltage-gated sodium channel activity [IDA]
- ATPase binding [ISS]
- HLH domain binding [IPI]
- actinin binding [IDA]
- calcium ion binding [ISS]
- calcium-induced calcium release activity [IDA]
- cytoskeletal protein binding [IDA]
- identical protein binding [IPI, ISS]
- ion channel binding [IPI]
- phosphoprotein binding [IPI]
- potassium channel activity [ISS]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- receptor binding [IPI]
- voltage-gated calcium channel activity [IDA]
- voltage-gated cation channel activity [IDA]
- voltage-gated ion channel activity [IDA]
- voltage-gated sodium channel activity [IDA]
Gene Ontology Cellular Component
- basal cortex [IDA]
- basal plasma membrane [IDA]
- cell-cell junction [ISS]
- ciliary basal body [IDA]
- cilium [ISS]
- cytoplasm [IDA, IMP]
- endoplasmic reticulum [IDA, IMP]
- endoplasmic reticulum membrane [IDA]
- extracellular vesicular exosome [IDA]
- filamentous actin [IDA]
- integral component of cytoplasmic side of endoplasmic reticulum membrane [IDA]
- integral component of lumenal side of endoplasmic reticulum membrane [IDA]
- integral component of plasma membrane [IDA]
- lamellipodium [IDA]
- mitotic spindle [IDA]
- motile primary cilium [ISS]
- nonmotile primary cilium [ISS]
- plasma membrane [IDA]
- polycystin complex [ISS]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Systematic identification of pathological lamin A interactors.
Laminopathies are a collection of phenotypically diverse diseases that include muscular dystrophies, cardiomyopathies, lipodystrophies, and premature aging syndromes. Laminopathies are caused by >300 distinct mutations in the LMNA gene, which encodes the nuclear intermediate filament proteins lamin A and C, two major architectural elements of the mammalian cell nucleus. The genotype-phenotype relationship and the basis for the pronounced tissue specificity ... [more]
Mol. Biol. Cell May. 01, 2014; 25(9);1493-510 [Pubmed: 24623722]
Throughput
- High Throughput
Curated By
- BioGRID