BAIT

COA6

C1orf31, RP5-827C21.3

cytochrome c oxidase assembly factor 6

GO Process (0)

GO Function (1)

GO Component (1)

Gene Ontology Molecular Function

poly(A) RNA binding [IDA]

Gene Ontology Cellular Component

mitochondrion [ISS]

CRISPR Database VEGA OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

COX2

COII, MTCO2

cytochrome c oxidase subunit II

GO Process (0)

GO Function (0)

GO Component (0)

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Homo sapiens

Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Publication

Cooperation between COA6 and SCO2 in COX2 maturation during cytochrome c oxidase assembly links two mitochondrial cardiomyopathies.

Pacheu-Grau D, Bareth B, Dudek J, Juris L, Voegtle FN, Wissel M, Leary SC, Dennerlein S, Rehling P, Deckers M

Three mitochondria-encoded subunits form the catalytic core of cytochrome c oxidase, the terminal enzyme of the respiratory chain. COX1 and COX2 contain heme and copper redox centers, which are integrated during assembly of the enzyme. Defects in this process lead to an enzyme deficiency and manifest as mitochondrial disorders in humans. Here we demonstrate that COA6 is specifically required for ... [more]

Cell Metab. Jun. 02, 2015; 21(6);823-33 [Pubmed: 25959673]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary