BAIT
GTF2IRD1
BEN, CREAM1, GTF3, MUSTRD1, RBAP2, WBS, WBSCR11, WBSCR12, hMusTRD1alpha1
GTF2I repeat domain containing 1
GO Process (3)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
VIMP
ADO15, SBBI8, SELS, SEPS1, AD-015
VCP-interacting membrane protein
GO Process (22)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- ER overload response [IDA, IMP]
- ER-associated ubiquitin-dependent protein catabolic process [IDA]
- cell redox homeostasis [IDA]
- cellular response to insulin stimulus [TAS]
- cellular response to lipopolysaccharide [IMP]
- cellular response to oxidative stress [IMP]
- endoplasmic reticulum unfolded protein response [IDA]
- establishment of protein localization [TAS]
- negative regulation of acute inflammatory response to antigenic stimulus [IMP]
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [IMP]
- negative regulation of glucose import [TAS]
- negative regulation of glycogen biosynthetic process [TAS]
- negative regulation of inflammatory response [IC]
- negative regulation of interleukin-6 production [ISS]
- negative regulation of macrophage apoptotic process [IMP]
- negative regulation of nitric-oxide synthase biosynthetic process [IMP]
- negative regulation of tumor necrosis factor production [ISS]
- regulation of gluconeogenesis [TAS]
- regulation of nitric oxide metabolic process [IMP]
- response to glucose [IEP]
- response to redox state [IDA]
- retrograde protein transport, ER to cytosol [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation.
GTF2IRD1 is one of the three members of the GTF2I gene family, clustered on chromosome 7 within a 1.8 Mb region that is prone to duplications and deletions in humans. Hemizygous deletions cause Williams-Beuren syndrome (WBS) and duplications cause WBS duplication syndrome. These copy number variations disturb a variety of developmental systems and neurological functions. Human mapping data and analyses ... [more]
Hum. Genet. Oct. 01, 2015; 134(10);1099-115 [Pubmed: 26275350]
Throughput
- High Throughput
Additional Notes
- Two independent screens done with human and mouse libraries; results do not specify source of hit
Curated By
- BioGRID