BAIT
RSC1A1
RS1
regulatory solute carrier protein, family 1, member 1
GO Process (2)
GO Function (1)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SOD2
IPOB, MNSOD, MVCD6, RP1-56L9.2
superoxide dismutase 2, mitochondrial
GO Process (13)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- age-dependent response to reactive oxygen species [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of neuron apoptotic process [IGI]
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [IMP]
- oxygen homeostasis [IMP]
- protein homotetramerization [IPI]
- regulation of blood pressure [ISS]
- regulation of transcription from RNA polymerase II promoter [IMP]
- release of cytochrome c from mitochondria [ISS]
- removal of superoxide radicals [IMP]
- response to superoxide [IMP]
- superoxide metabolic process [IDA]
- vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Protein RS1 (RSC1A1) Downregulates the Exocytotic Pathway of Glucose Transporter SGLT1 at Low Intracellular Glucose via Inhibition of Ornithine Decarboxylase.
Na+-d-glucose cotransporter 1 (SGLT1) is rate-limiting for glucose absorption in the small intestine. Shortly after intake of glucose-rich food, SGLT1 abundance in the luminal membrane of the small intestine is increased. This upregulation occurs via glucose-induced acceleration of the release of SGLT1-containing vesicles from the trans-Golgi network (TGN), which is regulated by a domain of protein RS1 (RSC1A1) named RS1-Reg. ... [more]
Mol. Pharmacol. Nov. 01, 2016; 90(5);508-521 [Pubmed: 27555600]
Throughput
- Low Throughput
Curated By
- BioGRID