Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Publication

Ethanol-triggered Lipophagy Requires SQSTM1 in AML12 Hepatic Cells.

Wang L, Zhou J, Yan S, Lei G, Lee CH, Yin XM

Ethanol-induced hepatic lipophagy plays an important cytoprotective role against liver injury, but its mechanism is not fully determined. In the present study, ethanol-induced lipophagy was studied in an immortalized mouse hepatocyte line, AML12. We found that ethanol treatment elevated lipid content in these cells, which could be regulated by autophagy. To determine the potential mechanism, we investigated the role of ... [more]

Sci Rep Sep. 26, 2017; 7(1);12307 [Pubmed: 28951592]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

MAP1LC3A

Gene Ontology Biological Process

Gene Ontology Molecular Function

GABA receptor binding [IBA]microtubule binding [IBA]phosphatidylethanolamine binding [IDA]phospholipid binding [IDA]protein binding [IPI]

Gene Ontology Cellular Component

PLIN1