BAIT
RPD3
MOF6, REC3, SDI2, SDS6, histone deacetylase RPD3, L000001696, L000001603, YNL330C
Histone deacetylase, component of both the Rpd3S and Rpd3L complexes; regulates transcription, silencing, autophagy and other processes by influencing chromatin remodeling; forms at least two different complexes which have distinct functions and members; Rpd3(L) recruitment to the subtelomeric region is regulated by interaction with the arginine methyltransferase, Hmt1p
GO Process (19)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
- chromatin organization involved in regulation of transcription [IMP]
- histone H3 deacetylation [IMP]
- histone H4 deacetylation [IMP]
- negative regulation of chromatin silencing at rDNA [IMP]
- negative regulation of chromatin silencing at silent mating-type cassette [IMP]
- negative regulation of chromatin silencing at telomere [IDA, IMP]
- negative regulation of reciprocal meiotic recombination [IMP]
- negative regulation of transcription during meiosis [IMP]
- negative regulation of transcription from RNA polymerase I promoter [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IGI, IMP, IPI]
- positive regulation of macroautophagy [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IGI, IMP]
- protein localization to nucleolar rDNA repeats [IMP]
- regulation of DNA-dependent DNA replication initiation [IGI, IMP]
- regulation of transcription involved in G1/S transition of mitotic cell cycle [IGI, IPI]
- regulation of transcription involved in G2/M transition of mitotic cell cycle [IGI]
- replicative cell aging [IMP]
- transcription elongation from RNA polymerase II promoter [IGI]
- transfer RNA gene-mediated silencing [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
AMN1
CST13, ICS4, L000002997, YBR158W
Protein required for daughter cell separation; multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
GO Process (2)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
Dosage Lethality
A genetic interaction is inferred when over expression or increased dosage of one gene causes lethality in a strain that is mutated or deleted for another gene.
Publication
Direct in vivo access to potential gene targets of the RPD3 histone deactylase using fitness-based interferential genetics.
Using the fitness-based interferential genetics (FIG) approach in yeast, potential in vivo gene targets of the Rpd3 histone deacetylase were selected. In agreement with previous studies using different methods, three genes were found to be involved in the translational machinery (MRPL27, FHL1 and RDN1). Moreover, other selected genes are linked to cell-cycle control (CSE4, AMN1, VAC17 and GRR1). In addition ... [more]
Yeast Jul. 01, 2007; 24(7);575-87 [Pubmed: 17533620]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
Curated By
- BioGRID