BAIT

UHRF2

NIRF, RNF107, URF2, RP11-472F14.2
ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
UPS Project
Homo sapiens
PREY

BMI1

FLVI2/BMI1, PCGF4, RNF51, RP11-573G6.1
BMI1 proto-oncogene, polycomb ring finger
UPS Project
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Multidimensional Proteomics Reveals a Role of UHRF2 in the Regulation of Epithelial-Mesenchymal Transition (EMT).

Lai M, Liang L, Chen J, Qiu N, Ge S, Ji S, Shi T, Zhen B, Liu M, Ding C, Wang Y, Qin J

UHRF1 is best known for its positive role in the maintenance of DNMT1-mediated DNA methylation and is implicated in a variety of tumor processes. In this paper, we provided evidence to demonstrate a role of UHRF2 in cell motility and invasion through the regulation of the epithelial-mesenchymal transition (EMT) process by acting as a transcriptional co-regulator of the EMT-transcription factors ... [more]

Mol. Cell Proteomics Dec. 01, 2015; 15(7);2263-78 [Pubmed: 27114453]

Throughput

  • High Throughput

Curated By

  • BioGRID