BAIT
FAM107A
DRR1, TU3A
family with sequence similarity 107, member A
GO Process (1)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Homo sapiens
PREY
CPSF3
CPSF-73, CPSF73
cleavage and polyadenylation specific factor 3, 73kDa
GO Process (10)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- RNA splicing [TAS]
- gene expression [TAS]
- histone mRNA 3'-end processing [IDA]
- mRNA 3'-end processing [TAS]
- mRNA cleavage [TAS]
- mRNA export from nucleus [TAS]
- mRNA polyadenylation [TAS]
- mRNA splicing, via spliceosome [TAS]
- termination of RNA polymerase II transcription [TAS]
- transcription from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A novel nuclear complex of DRR1, F-actin and COMMD1 involved in NF-κB degradation and cell growth suppression in neuroblastoma.
Downregulated in renal cell carcinoma 1 (DRR1) has important roles in tumor cell growth, neuron survival and spine formation, and was recently shown to bind actin. However, the roles of nuclear DRR1 remain largely unexplored. Here, we identified an interaction between filamentous actin (F-actin) and DRR1 in the nucleus, and demonstrated that copper metabolism MURR1 domain-containing 1 (COMMD1) is another ... [more]
Oncogene Oct. 12, 2017; 36(41);5745-5756 [Pubmed: 28604741]
Throughput
- Low Throughput
Curated By
- BioGRID