BAIT

FAM107A

DRR1, TU3A

family with sequence similarity 107, member A

GO Process (1)

GO Function (0)

GO Component (1)

Gene Ontology Biological Process

regulation of cell growth [IDA]

Gene Ontology Cellular Component

nucleus [IDA]

CRISPR Database HGNC Alliance of Genome Resources VEGA OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

EFHC2

MRX74, dJ1158H2.1, RP11-334D18.1

EF-hand domain (C-terminal) containing 2

GO Process (0)

GO Function (0)

GO Component (0)

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB HPRD

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

A novel nuclear complex of DRR1, F-actin and COMMD1 involved in NF-ÎºB degradation and cell growth suppression in neuroblastoma.

Mu P, Akashi T, Lu F, Kishida S, Kadomatsu K

Downregulated in renal cell carcinoma 1 (DRR1) has important roles in tumor cell growth, neuron survival and spine formation, and was recently shown to bind actin. However, the roles of nuclear DRR1 remain largely unexplored. Here, we identified an interaction between filamentous actin (F-actin) and DRR1 in the nucleus, and demonstrated that copper metabolism MURR1 domain-containing 1 (COMMD1) is another ... [more]

Oncogene Oct. 12, 2017; 36(41);5745-5756 [Pubmed: 28604741]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary