BAIT

MIB1

DIP-1, DIP1, LVNC7, MIB, ZZANK2, ZZZ6
mindbomb E3 ubiquitin protein ligase 1
UPS Project
GO Process (3)
GO Function (2)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

EPB41L4A

EPB41L4, NBL4
erythrocyte membrane protein band 4.1 like 4A
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Epb41l5 competes with Delta as a substrate for Mib1 to coordinate specification and differentiation of neurons.

Matsuda M, Rand K, Palardy G, Shimizu N, Ikeda H, Dalle Nogare D, Itoh M, Chitnis AB

We identified Erythrocyte membrane protein band 4.1-like 5 (Epb41l5) as a substrate for the E3 ubiquitin ligase Mind bomb 1 (Mib1), which is essential for activation of Notch signaling. Although loss of Epb41l5 does not significantly alter the pattern of neural progenitor cells (NPCs) specified as neurons at the neural plate stage, it delays their delamination and differentiation after neurulation ... [more]

Development Dec. 01, 2015; 143(17);3085-96 [Pubmed: 27510968]

Throughput

  • Low Throughput

Curated By

  • BioGRID