DLL1
Gene Ontology Biological Process
- Notch receptor processing [TAS]
- Notch signaling pathway [IMP, NAS, TAS]
- cell differentiation [TAS]
- cell fate determination [NAS]
- determination of left/right symmetry [ISS]
- heart looping [ISS]
- hemopoiesis [NAS]
- negative regulation of interleukin-10 production [IMP]
- neuronal stem cell maintenance [IEP]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- regulation of cell adhesion [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MIB1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Epb41l5 competes with Delta as a substrate for Mib1 to coordinate specification and differentiation of neurons.
We identified Erythrocyte membrane protein band 4.1-like 5 (Epb41l5) as a substrate for the E3 ubiquitin ligase Mind bomb 1 (Mib1), which is essential for activation of Notch signaling. Although loss of Epb41l5 does not significantly alter the pattern of neural progenitor cells (NPCs) specified as neurons at the neural plate stage, it delays their delamination and differentiation after neurulation ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MIB1 DLL1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 569262 |
Curated By
- BioGRID