CHEK1
Gene Ontology Biological Process
- DNA damage checkpoint [ISO, ISS]
- DNA damage induced protein phosphorylation [IMP, ISO]
- DNA repair [ISO]
- G2/M transition of mitotic cell cycle [ISO]
- cellular response to DNA damage stimulus [ISO, ISS]
- cellular response to caffeine [IEP]
- cellular response to mechanical stimulus [ISO]
- cellular response to organic substance [IEP]
- chromatin-mediated maintenance of transcription [ISO, ISS]
- histone H3-T11 phosphorylation [ISO]
- negative regulation of DNA biosynthetic process [IMP]
- negative regulation of G2/M transition of mitotic cell cycle [IMP]
- negative regulation of mitosis [ISO, ISS]
- peptidyl-threonine phosphorylation [ISO, ISS]
- protein phosphorylation [IDA, ISO]
- regulation of cell proliferation [ISO]
- regulation of double-strand break repair via homologous recombination [ISO, ISS]
- regulation of gene expression [ISO]
- regulation of histone H3-K9 acetylation [ISO, ISS]
- regulation of mitotic centrosome separation [ISO, ISS]
- regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CHEK1
Gene Ontology Biological Process
- DNA damage checkpoint [ISO, ISS]
- DNA damage induced protein phosphorylation [IMP, ISO]
- DNA repair [ISO]
- G2/M transition of mitotic cell cycle [ISO]
- cellular response to DNA damage stimulus [ISO, ISS]
- cellular response to caffeine [IEP]
- cellular response to mechanical stimulus [ISO]
- cellular response to organic substance [IEP]
- chromatin-mediated maintenance of transcription [ISO, ISS]
- histone H3-T11 phosphorylation [ISO]
- negative regulation of DNA biosynthetic process [IMP]
- negative regulation of G2/M transition of mitotic cell cycle [IMP]
- negative regulation of mitosis [ISO, ISS]
- peptidyl-threonine phosphorylation [ISO, ISS]
- protein phosphorylation [IDA, ISO]
- regulation of cell proliferation [ISO]
- regulation of double-strand break repair via homologous recombination [ISO, ISS]
- regulation of gene expression [ISO]
- regulation of histone H3-K9 acetylation [ISO, ISS]
- regulation of mitotic centrosome separation [ISO, ISS]
- regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Cloning and characterization of liver-specific isoform of Chk1 gene from rat.
We have isolated and characterized an isoform of protein kinase Chk1 gene from rat liver and a rat liver cDNA library by 5'-rapid amplification of cDNA ends. The gene (Cil) contains the C-terminal region of the Chk1 gene, but the 5'-end is derived from a sequence in the intron of Chk1 preceding the C-terminal domain by differential RNA splicing. The ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CHEK1 CHEK1 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID