BAIT
HEY1
BHLHb31, CHF2, HERP2, HESR1, HRT-1, OAF1, hHRT1
hes-related family bHLH transcription factor with YRPW motif 1
GO Process (24)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- Notch signaling involved in heart development [IC]
- Notch signaling pathway [IDA, TAS]
- angiogenesis [IEP]
- arterial endothelial cell differentiation [ISS]
- atrioventricular valve formation [ISS]
- cardiac epithelial to mesenchymal transition [ISS]
- cardiac septum morphogenesis [ISS]
- cardiac ventricle morphogenesis [ISS]
- dorsal aorta morphogenesis [ISS]
- endocardial cushion morphogenesis [ISS]
- epithelial to mesenchymal transition involved in endocardial cushion formation [ISS]
- heart trabecula formation [ISS]
- labyrinthine layer blood vessel development [ISS]
- negative regulation of Notch signaling pathway [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation [IDA]
- negative regulation of transcription regulatory region DNA binding [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- pulmonary valve morphogenesis [ISS]
- regulation of vasculogenesis [ISS]
- transcription from RNA polymerase II promoter [ISS]
- umbilical cord morphogenesis [ISS]
- ventricular septum morphogenesis [ISS]
Gene Ontology Molecular Function
Homo sapiens
PREY
RPL9
L9, NPC-A-16, OK/SW-cl.103
ribosomal protein L9
GO Process (13)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- SRP-dependent cotranslational protein targeting to membrane [TAS]
- cellular protein metabolic process [TAS]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [TAS]
- translation [NAS, TAS]
- translational elongation [TAS]
- translational initiation [TAS]
- translational termination [TAS]
- viral life cycle [TAS]
- viral process [TAS]
- viral transcription [TAS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
HEY1 functions are regulated by its phosphorylation at Ser-68.
HEY1 (hairy/enhancer-of-split related with YRPW motif 1) is a member of the basic helix-loop-helix-orange (bHLH-O) family of transcription repressors that mediate Notch signalling. HEY1 acts as a positive regulator of the tumour suppressor p53 via still unknown mechanisms. A MALDI-TOF/TOFÂ MS analysis has uncovered a novel HEY1 regulatory phosphorylation event at Ser-68. Strikingly, this single phosphorylation event controls HEY1 stability and ... [more]
Biosci. Rep. Jul. 01, 2016; 36(3); [Pubmed: 27129302]
Throughput
- High Throughput
Curated By
- BioGRID