BAIT
FRMD7
NYS, NYS1, XIPAN, RP6-213H19.2
FERM domain containing 7
GO Process (1)
GO Function (0)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
PREY
CASK
CAGH39, CAMGUK, CMG, FGS4, LIN2, MICPCH, MRXSNA, TNRC8, RP11-540L11.1
calcium/calmodulin-dependent serine protein kinase (MAGUK family)
GO Process (7)
GO Function (2)
GO Component (11)
Gene Ontology Biological Process
- cell adhesion [TAS]
- extracellular matrix organization [TAS]
- negative regulation of cell-matrix adhesion [IMP]
- negative regulation of cellular response to growth factor stimulus [IMP]
- negative regulation of keratinocyte proliferation [IMP]
- negative regulation of wound healing [IMP]
- nucleotide phosphorylation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A novel interaction between FRMD7 and CASK: evidence for a causal role in idiopathic infantile nystagmus.
Idiopathic infantile nystagmus (IIN) is a genetically heterogeneous disorder of eye movement that can be caused by mutations in the FRMD7 gene that encodes a FERM domain protein. FRMD7 is expressed in the brain and knock-down studies suggest it plays a role in neurite extension through modulation of the actin cytoskeleton, yet little is known about its precise molecular function ... [more]
Hum. Mol. Genet. May. 15, 2013; 22(10);2105-18 [Pubmed: 23406872]
Throughput
- Low Throughput
Additional Notes
- Also validated by affinity capture-western and colocalization
Curated By
- BioGRID