BAIT
PCBP1
HEL-S-85, HNRPE1, HNRPX, hnRNP-E1, hnRNP-X
poly(rC) binding protein 1
GO Process (3)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TRIM25
EFP, RNF147, Z147, ZNF147
tripartite motif containing 25
GO Process (7)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- innate immune response [IDA, TAS]
- negative regulation of type I interferon production [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- regulation of viral entry into host cell [IDA]
- regulation of viral release from host cell [IMP]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Poly r(C) binding protein (PCBP) 1 expression is regulated by the E3 ligase UBE4A in thyroid carcinoma.
Thyroid cancer patients with high miR-490-3p inhibit translation ofPCBP1mRNA, whereas in patients with low miR-490-3pPCBP1mRNA expression is high; however, the resultant protein is targeted for degradation through the proteasome. The objective of the present study was to evaluate the molecular mechanism that regulates post-translation degradation of poly r(C) binding protein (PCBP) 1 expression in thyroid cancer cells. Mass spectrometric analysis ... [more]
Biosci. Rep. Oct. 31, 2017; 37(5); [Pubmed: 28963376]
Throughput
- Low Throughput
Curated By
- BioGRID