IRS1
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- JAK-STAT cascade involved in growth hormone signaling pathway [TAS]
- cellular response to insulin stimulus [IMP]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- glucose homeostasis [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [IDA, IMP, IPI, TAS]
- insulin-like growth factor receptor signaling pathway [IPI]
- negative regulation of insulin receptor signaling pathway [ISS]
- negative regulation of insulin secretion [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol 3-kinase signaling [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of cell proliferation [NAS]
- positive regulation of fatty acid beta-oxidation [IMP]
- positive regulation of glucose import [IMP]
- positive regulation of glucose import in response to insulin stimulus [IDA]
- positive regulation of glucose metabolic process [IMP]
- positive regulation of glycogen biosynthetic process [IMP, NAS]
- positive regulation of insulin receptor signaling pathway [ISS]
- positive regulation of phosphatidylinositol 3-kinase activity [ISS]
- response to insulin [IDA]
- response to peptide hormone [ISS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CAV2
Gene Ontology Biological Process
- caveola assembly [ISO, ISS]
- endoplasmic reticulum organization [ISO, ISS]
- mitochondrion organization [ISO, ISS]
- negative regulation of cell proliferation [ISO]
- negative regulation of endothelial cell proliferation [IMP, ISO, ISS]
- negative regulation of transforming growth factor beta receptor signaling pathway [ISO]
- positive regulation of dopamine receptor signaling pathway [ISO, ISS]
- positive regulation of endothelial cell proliferation [ISO]
- protein oligomerization [ISO]
- regulation of mitosis [ISO]
- skeletal muscle fiber development [ISO, ISS]
- synaptic transmission [IDA]
- vesicle docking [ISO, ISS]
- vesicle fusion [ISO, ISS]
- vesicle organization [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- acrosomal membrane [ISO]
- caveola [IDA, ISO, ISS]
- cell surface [IDA]
- cytoplasm [IDA]
- cytoplasmic vesicle [ISO]
- cytosol [IDA]
- endoplasmic reticulum [IDA]
- extrinsic component of cytoplasmic side of plasma membrane [ISO, ISS]
- integral component of plasma membrane [ISO]
- intracellular [ISO]
- lipid particle [IDA]
- membrane [ISO]
- membrane raft [IDA, ISO]
- nuclear inner membrane [IDA]
- perinuclear region of cytoplasm [ISO, ISS]
- plasma membrane [IDA, ISO]
- protein complex [IDA, ISO]
- transport vesicle [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Fatty acylated caveolin-2 is a substrate of insulin receptor tyrosine kinase for insulin receptor substrate-1-directed signaling activation.
Here, we demonstrate that insulin receptor (IR) tyrosine kinase catalyzes Tyr-19 and Tyr-27 phosphorylation of caveolin-2 (cav-2), leading to stimulation of signaling proteins downstream of IR, and that the catalysis is dependent on fatty acylation status of cav-2, promoting its interaction with IR. Cav-2 is myristoylated at Gly-2 and palmitoylated at Cys-109, Cys-122, and Cys-145. The fatty acylation deficient mutants ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CAV2 IRS1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID