BioGRID COVID-19 Coronavirus Curation Project
Search BioGRID for SARS-CoV-2 Protein Interactions | Download SARS-CoV-2 and Coronavirus-Related Interactions

BAIT

MTF1

MTF-1, ZRF

metal-regulatory transcription factor 1

GO Process (3)

GO Function (7)

GO Component (2)

Gene Ontology Biological Process

positive regulation of transcription from RNA polymerase II promoter [IDA]

regulation of transcription from RNA polymerase II promoter [TAS]

response to metal ion [TAS]

Gene Ontology Molecular Function

DNA binding [TAS]
RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
core promoter binding [IDA]
protein binding [IPI]
sequence-specific DNA binding transcription factor activity [TAS]
transcription coactivator activity [TAS]

Gene Ontology Cellular Component

nucleoplasm [IDA]

CRISPR Database VEGA OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

EEF1A1

CCS-3, CCS3, EE1A1, EEF-1, EEF1A, EF-Tu, EF1A, GRAF-1EF, HNGC:16303, LENG7, PTI1, eEF1A-1, RP11-505P4.2

eukaryotic translation elongation factor 1 alpha 1

GO Process (5)

GO Function (5)

GO Component (8)

Gene Ontology Biological Process

cellular protein metabolic process [TAS]

cellular response to epidermal growth factor stimulus [IDA]

gene expression [TAS]

translation [TAS]

translational elongation [TAS]

Gene Ontology Molecular Function

GTP binding [TAS]
poly(A) RNA binding [IDA]
protein binding [IPI]
protein kinase binding [IPI]
translation elongation factor activity [TAS]

Gene Ontology Cellular Component

cytoplasm [IDA, ISS, TAS]

eukaryotic translation elongation factor 1 complex [TAS]

extracellular space [IDA]

extracellular vesicular exosome [IDA]

nucleolus [IDA]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Nuclear organization of nucleotide excision repair is mediated by RING1B dependent H2A-ubiquitylation.

Chitale S, Richly H

One of the major cellular DNA repair pathways is nucleotide excision repair (NER). It is the primary pathway for repair of various DNA lesions caused by exposure to ultraviolet (UV) light, such as cyclobutane pyrimidine dimers (CPDs) and 6-4 photoproducts. Although lesion-containing DNA associates with the nuclear matrix after UV irradiation it is still not understood how nuclear organization affects ... [more]

Oncotarget May. 09, 2017; 8(19);30870-30887 [Pubmed: 28416769]

Throughput

High Throughput

Additional Notes

mass spec analysis was unable to distinguish between then following groups of proteins: HNRNPA1/HNRNPA1L2, RBMX/RBMXL1, DDX3X/DDX3Y, RPLP0/RPLP0P6, ATAD3A/ATAD3B, EEF1A1P5/EEF1A1/EEF1A2

Curated By

BioGRID