WWC1
Gene Ontology Biological Process
- cell migration [IDA]
- establishment of cell polarity [TAS]
- hippo signaling [TAS]
- negative regulation of hippo signaling [IDA]
- negative regulation of organ growth [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of MAPK cascade [IDA]
- regulation of hippo signaling [IMP]
- regulation of intracellular transport [TAS]
Gene Ontology Molecular Function
DAG1
Gene Ontology Biological Process
- NLS-bearing protein import into nucleus [IDA]
- cytoskeletal anchoring at plasma membrane [IMP]
- extracellular matrix organization [TAS]
- membrane protein ectodomain proteolysis [IDA]
- microtubule anchoring [IMP]
- modulation by virus of host morphology or physiology [IDA]
- negative regulation of MAPK cascade [IMP]
- negative regulation of cell migration [IMP]
- negative regulation of protein kinase B signaling [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- basement membrane [IDA]
- contractile ring [IDA]
- cytoplasm [IDA]
- dystrophin-associated glycoprotein complex [IDA]
- extracellular region [TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- filopodium [IDA]
- focal adhesion [IDA]
- integral component of membrane [IDA]
- lamellipodium [IDA]
- nucleoplasm [IDA]
- plasma membrane [IDA, TAS]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Deubiquitinating Enzyme USP9X Suppresses Tumor Growth via LATS Kinase and Core Components of the Hippo Pathway.
The core LATS kinases of the Hippo tumor suppressor pathway phosphorylate and inhibit the downstream transcriptional co-activators YAP and TAZ, which are implicated in various cancers. Recent studies have identified various E3 ubiquitin ligases that negatively regulate the Hippo pathway via ubiquitination, yet few deubiquitinating enzymes (DUB) have been implicated. In this study, we report the DUB USP9X is an ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| WWC1 DAG1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3282822 | |
| WWC1 DAG1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3058370 |
Curated By
- BioGRID