BAIT
PPP2CA
PP2Ac, PP2CA, PP2Calpha, RP-C
protein phosphatase 2, catalytic subunit, alpha isozyme
GO Process (24)
GO Function (1)
GO Component (7)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- RNA splicing [NAS]
- apoptotic process [TAS]
- ceramide metabolic process [NAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- gene expression [TAS]
- inactivation of MAPK activity [NAS]
- mRNA metabolic process [TAS]
- mitotic cell cycle [TAS]
- mitotic nuclear envelope reassembly [TAS]
- negative regulation of cell growth [NAS]
- negative regulation of epithelial to mesenchymal transition [IMP]
- negative regulation of tyrosine phosphorylation of Stat3 protein [NAS]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [TAS]
- positive regulation of protein serine/threonine kinase activity [IMP]
- protein dephosphorylation [TAS]
- regulation of DNA replication [NAS]
- regulation of Wnt signaling pathway [NAS]
- regulation of cell adhesion [NAS]
- regulation of cell differentiation [NAS]
- regulation of growth [NAS]
- regulation of transcription, DNA-templated [NAS]
- response to organic substance [NAS]
- second-messenger-mediated signaling [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CEBPA
C/ebpalpha, CBF-A, Cebp
CCAAT/enhancer binding protein (C/EBP), alpha
GO Process (29)
GO Function (16)
GO Component (6)
Gene Ontology Biological Process
- brown fat cell differentiation [IDA]
- cell maturation [IMP]
- cellular response to lithium ion [IDA]
- cellular response to organic cyclic compound [IDA]
- cholesterol metabolic process [IMP]
- cytokine-mediated signaling pathway [NAS]
- embryonic placenta development [IGI]
- fat cell differentiation [IDA]
- inner ear development [IDA]
- liver development [IMP]
- lung development [IMP]
- macrophage differentiation [IMP]
- mitochondrion organization [IMP]
- myeloid cell differentiation [IDA]
- negative regulation of cell proliferation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of fat cell differentiation [IDA, ISO]
- positive regulation of osteoblast differentiation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription from RNA polymerase III promoter [ISO]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of cell proliferation [IMP]
- regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [IDA, ISO, NAS]
- transcription from RNA polymerase II promoter [IDA]
- transcription, DNA-templated [ISO, NAS]
- urea cycle [IDA]
- white fat cell differentiation [IMP]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- HMG box domain binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [IDA, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO, NAS]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [IDA, ISO]
- DNA binding [IDA, ISO]
- HMG box domain binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [IDA, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO, NAS]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [IDA, ISO]
Gene Ontology Cellular Component
Mus musculus
Biochemical Activity (Dephosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity.
Liver tumor cells arise from normal hepatocytes that escape negative control of proliferation. The transcription factor C/EBPalpha maintains quiescence of hepatocytes through two pathways: inhibition of cdks and repression of E2F. Nevertheless, liver tumors and cultured hepatoma cell lines proliferate in the presence of C/EBPalpha. In this paper, we present evidence that the activation of the PI3K/Akt pathway in liver ... [more]
Genes Dev. Apr. 15, 2004; 18(8);912-25 [Pubmed: 15107404]
Throughput
- Low Throughput
Curated By
- BioGRID