BAIT
ADRA1A
ADRA1C, ADRA1L1, ALPHA1AAR
adrenoceptor alpha 1A
GO Process (22)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- activation of phospholipase C activity [ISS]
- adrenergic receptor signaling pathway [ISS, NAS, TAS]
- aging [ISS]
- apoptotic process [TAS]
- calcium ion transport into cytosol [ISS]
- cell-cell signaling [TAS]
- intracellular signal transduction [TAS]
- negative regulation of Rho protein signal transduction [ISS]
- negative regulation of cell proliferation [TAS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of MAPK cascade [IDA]
- positive regulation of action potential [ISS]
- positive regulation of cardiac muscle contraction [ISS]
- positive regulation of cytosolic calcium ion concentration [ISS]
- positive regulation of protein kinase C signaling [ISS]
- positive regulation of synaptic transmission, GABAergic [ISS]
- positive regulation of vasoconstriction [ISS]
- response to drug [ISS]
- response to hormone [ISS]
- signal transduction [TAS]
- smooth muscle contraction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ADRA1A
ADRA1C, ADRA1L1, ALPHA1AAR
adrenoceptor alpha 1A
GO Process (22)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- activation of phospholipase C activity [ISS]
- adrenergic receptor signaling pathway [ISS, NAS, TAS]
- aging [ISS]
- apoptotic process [TAS]
- calcium ion transport into cytosol [ISS]
- cell-cell signaling [TAS]
- intracellular signal transduction [TAS]
- negative regulation of Rho protein signal transduction [ISS]
- negative regulation of cell proliferation [TAS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of MAPK cascade [IDA]
- positive regulation of action potential [ISS]
- positive regulation of cardiac muscle contraction [ISS]
- positive regulation of cytosolic calcium ion concentration [ISS]
- positive regulation of protein kinase C signaling [ISS]
- positive regulation of synaptic transmission, GABAergic [ISS]
- positive regulation of vasoconstriction [ISS]
- response to drug [ISS]
- response to hormone [ISS]
- signal transduction [TAS]
- smooth muscle contraction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
FRET
An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.
Publication
Oligomerization of the alpha 1a- and alpha 1b-adrenergic receptor subtypes. Potential implications in receptor internalization.
We combined biophysical, biochemical, and pharmacological approaches to investigate the ability of the alpha 1a- and alpha 1b-adrenergic receptor (AR) subtypes to form homo- and hetero-oligomers. Receptors tagged with different epitopes (hemagglutinin and Myc) or fluorescent proteins (cyan and green fluorescent proteins) were transiently expressed in HEK-293 cells either individually or in different combinations. Fluorescence resonance energy transfer measurements provided ... [more]
J. Biol. Chem. Oct. 10, 2003; 278(41);40239-51 [Pubmed: 12888550]
Throughput
- Low Throughput
Curated By
- BioGRID