BAIT

RGS4

RGP4, SCZD9, RP11-430G6.1
regulator of G-protein signaling 4
GO Process (2)
GO Function (2)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

GNAO1

EIEE17, G-ALPHA-o, GNAO
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Selective regulation of Gq signaling by G protein-coupled receptor kinase 2: direct interaction of kinase N terminus with activated galphaq.

Sallese M, Mariggio S, D'Urbano E, Iacovelli L, De Blasi A

In this study, we investigated the regulation of different G protein-coupled receptor (GPCR)-stimulated signaling pathways by GPCR kinase 2 (GRK2). We used thyrotropin receptor, which is coupled to different G proteins, to investigate the regulation of Galphas- and Galphaq-mediated signaling (assessed by cAMP and inositol phosphate production, respectively). In transfected cells, both pathways were desensitized by GRK2. However a kinase-dead ... [more]

Mol. Pharmacol. Apr. 01, 2000; 57(4);826-31 [Pubmed: 10727532]

Throughput

  • Low Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
RGS4 GNAO1
Reconstituted Complex
Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Low-BioGRID
-

Curated By

  • BioGRID