VANGL2
Gene Ontology Biological Process
- Rho protein signal transduction [IMP]
- Wnt signaling pathway, planar cell polarity pathway [IGI, IMP]
- anterior/posterior pattern specification [IMP]
- apical protein localization [IMP]
- cardiac vascular smooth muscle cell differentiation [TAS]
- cell migration involved in kidney development [IMP]
- cochlea development [IGI]
- cochlea morphogenesis [IGI, IMP]
- convergent extension involved in axis elongation [IMP]
- convergent extension involved in neural plate elongation [IGI, IMP]
- convergent extension involved in organogenesis [IGI]
- digestive tract morphogenesis [IGI]
- epicardial cell to mesenchymal cell transition [TAS]
- establishment of body hair planar orientation [IMP]
- establishment of epithelial cell polarity [TAS]
- establishment of planar polarity [IGI, IMP]
- establishment of planar polarity involved in neural tube closure [IMP]
- establishment or maintenance of epithelial cell apical/basal polarity [IMP]
- glomerulus development [IMP]
- hair follicle development [IMP]
- heart looping [IMP]
- inner ear receptor cell development [IGI]
- inner ear receptor stereocilium organization [IGI, IMP]
- kidney morphogenesis [IMP]
- lateral sprouting involved in lung morphogenesis [IMP]
- membranous septum morphogenesis [IGI]
- muscular septum morphogenesis [IGI]
- neural tube closure [IGI, IMP]
- non-canonical Wnt signaling pathway [IMP]
- nonmotile primary cilium assembly [IGI]
- orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis [IMP]
- outflow tract septum morphogenesis [TAS]
- patterning of blood vessels [TAS]
- planar cell polarity pathway involved in axis elongation [IGI]
- planar cell polarity pathway involved in heart morphogenesis [IMP]
- planar cell polarity pathway involved in neural tube closure [IGI, IMP]
- planar dichotomous subdivision of terminal units involved in lung branching morphogenesis [IMP]
- positive regulation of JUN kinase activity [IGI]
- post-anal tail morphogenesis [IMP]
- regulation of Wnt signaling pathway [IMP]
- regulation of actin cytoskeleton organization [IMP]
- regulation of establishment of planar polarity [IGI]
- somatic stem cell division [IMP]
- somatic stem cell maintenance [IMP]
- wound healing [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RNF41
Gene Ontology Biological Process
- extrinsic apoptotic signaling pathway [ISO]
- negative regulation of cell migration [ISO]
- negative regulation of cell proliferation [ISO]
- positive regulation of reactive oxygen species metabolic process [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- proteasomal protein catabolic process [ISO]
- protein autoubiquitination [ISO]
- protein polyubiquitination [IDA, ISO]
- protein ubiquitination [IDA]
- regulation of MAPK cascade [ISO]
- regulation of establishment of cell polarity [IDA]
- regulation of gene expression [IDA]
- regulation of lymphocyte differentiation [IDA]
- regulation of myeloid cell differentiation [IDA]
- regulation of protein kinase B signaling [ISO]
- regulation of reactive oxygen species metabolic process [ISO]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Suppression of planar cell polarity signaling and migration in glioblastoma by Nrdp1-mediated Dvl polyubiquitination.
The lethality of the aggressive brain tumor glioblastoma multiforme (GBM) results in part from its strong propensity to invade surrounding normal brain tissue. Although oncogenic drivers such as epidermal growth factor receptor activation and Phosphatase and Tensin homolog inactivation are thought to promote the motility and invasiveness of GBM cells via phosphatidylinostitol 3-kinase activation, other unexplored mechanisms may also contribute ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID