BAIT
URI1
C19orf2, NNX3, PPP1R19, RMP, URI
URI1, prefoldin-like chaperone
GO Process (8)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- cellular response to growth factor stimulus [IDA]
- cellular response to steroid hormone stimulus [IDA]
- negative regulation of intrinsic apoptotic signaling pathway [IMP]
- negative regulation of phosphatase activity [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of cell growth [IDA]
- regulation of transcription from RNA polymerase II promoter [IMP]
- response to virus [IMP]
Gene Ontology Molecular Function
Homo sapiens
PREY
PCBP2
HNRNPE2, HNRPE2, hnRNP-E2
poly(rC) binding protein 2
GO Process (8)
GO Function (5)
GO Component (7)
Gene Ontology Biological Process
- RNA splicing [TAS]
- gene expression [TAS]
- innate immune response [TAS]
- mRNA metabolic process [NAS]
- mRNA splicing, via spliceosome [TAS]
- negative regulation of defense response to virus [IMP]
- negative regulation of type I interferon production [TAS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
URI Regulates KAP1 Phosphorylation and Transcriptional Repression via PP2A Phosphatase in Prostate Cancer Cells.
URI (unconventional prefoldin RPB5 interactor protein) is an unconventional prefoldin, RNA polymerase II interactor that functions as a transcriptional repressor and is part of a larger nuclear protein complex. The components of this complex and the mechanism of transcriptional repression have not been characterized. Here we show that KAP1 (KRAB-associated protein 1) and the protein phosphatase PP2A interact with URI. ... [more]
J. Biol. Chem. Dec. 02, 2016; 291(49);25516-25528 [Pubmed: 27780869]
Throughput
- High Throughput
Curated By
- BioGRID