BAIT
NOTCH1
AOS5, AOVD1, TAN1, hN1
notch 1
GO Process (77)
GO Function (5)
GO Component (9)
Gene Ontology Biological Process
- Notch receptor processing [TAS]
- Notch signaling involved in heart development [IMP]
- Notch signaling pathway [IMP, TAS]
- aortic valve morphogenesis [IMP]
- arterial endothelial cell differentiation [ISS]
- atrioventricular valve morphogenesis [ISS]
- cardiac atrium morphogenesis [ISS]
- cardiac chamber formation [ISS]
- cardiac epithelial to mesenchymal transition [ISS]
- cardiac left ventricle morphogenesis [ISS]
- cardiac muscle tissue morphogenesis [ISS]
- cardiac right atrium morphogenesis [ISS]
- cardiac septum morphogenesis [ISS]
- cardiac vascular smooth muscle cell development [ISS]
- cardiac ventricle morphogenesis [ISS]
- cell migration involved in endocardial cushion formation [ISS]
- cellular response to follicle-stimulating hormone stimulus [IDA]
- cellular response to vascular endothelial growth factor stimulus [IDA]
- cilium morphogenesis [ISS]
- coronary artery morphogenesis [ISS]
- coronary vein morphogenesis [ISS]
- determination of left/right symmetry [ISS]
- endocardial cell differentiation [ISS]
- endocardial cushion morphogenesis [ISS]
- endocardium development [ISS]
- endocardium morphogenesis [ISS]
- epithelial to mesenchymal transition [ISS]
- epithelial to mesenchymal transition involved in endocardial cushion formation [ISS]
- gene expression [TAS]
- growth involved in heart morphogenesis [ISS]
- heart development [IMP]
- heart looping [ISS]
- heart trabecula morphogenesis [ISS]
- immune response [NAS]
- mesenchymal cell development [ISS]
- mitral valve formation [IMP]
- negative regulation of BMP signaling pathway [ISS]
- negative regulation of anoikis [IMP]
- negative regulation of catalytic activity [ISS]
- negative regulation of cell migration involved in sprouting angiogenesis [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of cell-substrate adhesion [IDA]
- negative regulation of endothelial cell chemotaxis [IDA]
- negative regulation of glial cell proliferation [ISS]
- negative regulation of myoblast differentiation [IMP]
- negative regulation of myotube differentiation [ISS]
- negative regulation of neurogenesis [ISS]
- negative regulation of oligodendrocyte differentiation [ISS]
- negative regulation of ossification [ISS]
- negative regulation of osteoblast differentiation [ISS]
- negative regulation of pro-B cell differentiation [ISS]
- negative regulation of stem cell differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- negative regulation of transcription, DNA-templated [ISS]
- neuronal stem cell maintenance [IEP]
- pericardium morphogenesis [ISS]
- positive regulation of BMP signaling pathway [ISS]
- positive regulation of JAK-STAT cascade [ISS]
- positive regulation of astrocyte differentiation [ISS]
- positive regulation of cardiac muscle cell proliferation [ISS]
- positive regulation of cell migration [ISS]
- positive regulation of cell proliferation [IDA, IMP]
- positive regulation of epithelial to mesenchymal transition [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISS]
- positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [ISS]
- positive regulation of transcription of Notch receptor target [ISS]
- positive regulation of transcription, DNA-templated [ISS]
- pulmonary valve morphogenesis [IMP]
- regulation of extracellular matrix assembly [ISS]
- regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation [ISS]
- regulation of transcription, DNA-templated [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- tube formation [IMP]
- vasculogenesis involved in coronary vascular morphogenesis [ISS]
- venous endothelial cell differentiation [ISS]
- ventricular septum morphogenesis [IMP]
- ventricular trabecula myocardium morphogenesis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ADAM10
AD10, AD18, CD156c, HsT18717, MADM, RAK, kuz
ADAM metallopeptidase domain 10
GO Process (20)
GO Function (8)
GO Component (13)
Gene Ontology Biological Process
- Notch receptor processing [TAS]
- Notch signaling pathway [ISS, TAS]
- PMA-inducible membrane protein ectodomain proteolysis [IMP]
- cell-cell signaling [NAS]
- collagen catabolic process [TAS]
- constitutive protein ectodomain proteolysis [IDA]
- epidermal growth factor receptor signaling pathway [TAS]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- in utero embryonic development [ISS]
- integrin-mediated signaling pathway [NAS]
- membrane protein ectodomain proteolysis [IDA, IMP]
- monocyte activation [IMP]
- negative regulation of cell adhesion [IDA, NAS]
- positive regulation of T cell chemotaxis [IMP]
- positive regulation of cell growth [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [IMP]
- protein phosphorylation [ISS]
- response to tumor necrosis factor [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- Golgi-associated vesicle [IDA]
- cell surface [IDA]
- cytoplasm [ISS]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- integral component of membrane [NAS]
- intracellular membrane-bounded organelle [IDA]
- membrane [IDA]
- nucleus [ISS]
- perinuclear endoplasmic reticulum [IDA]
- plasma membrane [TAS]
- tetraspanin-enriched microdomain [IDA]
Homo sapiens
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Ligand-activated Notch undergoes DTX4-mediated ubiquitylation and bilateral endocytosis before ADAM10 processing.
The Notch signaling pathway, which is activated by cell-cell contact, is a major regulator of cell fate decisions. Mammalian Notch1 is present at the cell surface as a heterodimer of the Notch extracellular domain associated with the transmembrane and intracellular domains. After ligand binding, Notch undergoes proteolysis, releasing the Notch intracellular domain (NICD) that regulates gene expression. We monitored the ... [more]
Sci Signal Jun. 13, 2017; 10(483); [Pubmed: 28611181]
Throughput
- Low Throughput
Curated By
- BioGRID