An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Identification of the BRD1 interaction network and its impact on mental disorder risk.

Fryland T, Christensen JH, Pallesen J, Mattheisen M, Palmfeldt J, Bak M, Grove J, Demontis D, Blechingberg J, Ooi HS, Nyegaard M, Hauberg ME, Tommerup N, Gregersen N, Mors O, Corydon TJ, Nielsen AL, Borglum AD

The bromodomain containing 1 (BRD1) gene has been implicated with transcriptional regulation, brain development, and susceptibility to schizophrenia and bipolar disorder. To advance the understanding of BRD1 and its role in mental disorders, we characterized the protein and chromatin interactions of the BRD1 isoforms, BRD1-S and BRD1-L.Stable human cell lines expressing epitope tagged BRD1-S and BRD1-L were generated and used ... [more]

Genome Med Dec. 03, 2015; 8(1);53 [Pubmed: 27142060]

Throughput

Low Throughput

Additional Notes

interaction with Brd1 long isoform Brd1l
interaction with Brd1 short isoform Brd1s

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
YWHAZ BRD1	Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.	Segal D (2023)	High	-	BioGRID	3535835

Curated By

BioGRID

Interaction Summary

BRD1

Gene Ontology Biological Process

Gene Ontology Molecular Function

histone binding [IDA]

Gene Ontology Cellular Component

YWHAZ