HTR2A
Gene Ontology Biological Process
- activation of phospholipase C activity [IDA]
- cellular calcium ion homeostasis [IDA]
- phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of phosphatidylinositol biosynthetic process [IDA]
- release of sequestered calcium ion into cytosol [IDA, IMP]
- response to drug [IDA]
- serotonin receptor signaling pathway [IMP]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ARF6
Gene Ontology Biological Process
- GTP catabolic process [TAS]
- cell adhesion [TAS]
- cellular component movement [TAS]
- cortical actin cytoskeleton organization [IMP]
- negative regulation of receptor-mediated endocytosis [TAS]
- positive regulation of actin filament polymerization [IMP]
- positive regulation of establishment of protein localization to plasma membrane [ISS]
- protein localization to cell surface [ISS]
- protein localization to endosome [IMP]
- regulation of Rac protein signal transduction [IDA]
- regulation of dendritic spine development [ISS]
- regulation of filopodium assembly [IDA]
- ruffle organization [IDA]
- vesicle-mediated transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Role of the conserved NPxxY motif of the 5-HT2A receptor in determining selective interaction with isoforms of ADP-ribosylation factor (ARF).
In this study we have shown that N376 to D mutation in the conserved NPxxY motif within the carboxy terminal tail domain (CT) of the 5-HT2A receptor alters the binding preference of GST-fusion protein constructs of the CT domain from ARF1 to an alternative isoform, ARF6. These findings were corroborated by experiments investigating co-immunoprecipitation of the wild type (WT) and ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HTR2A ARF6 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| HTR2A ARF6 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID