BAIT
MAPK1
Erk2
mitogen activated protein kinase 1
GO Process (37)
GO Function (12)
GO Component (19)
Gene Ontology Biological Process
- B cell receptor signaling pathway [ISO]
- ERBB signaling pathway [ISO]
- ERK1 and ERK2 cascade [ISO]
- MAPK cascade [IMP, ISO]
- MAPK import into nucleus [IDA]
- T cell receptor signaling pathway [ISO]
- caveolin-mediated endocytosis [TAS]
- cellular response to DNA damage stimulus [ISO]
- cellular response to granulocyte macrophage colony-stimulating factor stimulus [ISO]
- cellular response to organic substance [IDA]
- cytosine metabolic process [ISO]
- intracellular signal transduction [IDA, TAS]
- labyrinthine layer blood vessel development [ISO]
- lipopolysaccharide-mediated signaling pathway [ISO]
- mammary gland epithelial cell proliferation [ISO]
- negative regulation of cell differentiation [ISO]
- organ morphogenesis [ISO]
- peptidyl-serine phosphorylation [IDA, IMP, ISO]
- peptidyl-threonine phosphorylation [ISO, ISS]
- positive regulation of cell migration [IEP]
- positive regulation of cell proliferation [IEP]
- positive regulation of peptidyl-threonine phosphorylation [ISO]
- positive regulation of transcription, DNA-templated [IEP]
- positive regulation of translation [IMP]
- protein phosphorylation [IDA, ISO, TAS]
- regulation of Golgi inheritance [TAS]
- regulation of cytoskeleton organization [TAS]
- regulation of early endosome to late endosome transport [TAS]
- regulation of protein stability [ISS]
- regulation of stress-activated MAPK cascade [TAS]
- response to epidermal growth factor [ISO, ISS]
- response to estrogen [IDA]
- response to exogenous dsRNA [ISO]
- response to lipopolysaccharide [ISO]
- response to toxic substance [IDA]
- sensory perception of pain [IMP]
- signal transduction [IDA]
Gene Ontology Molecular Function- ATP binding [IDA]
- MAP kinase activity [IDA, IMP, ISO, TAS]
- RNA polymerase II carboxy-terminal domain kinase activity [ISO]
- kinase activity [ISO, TAS]
- mitogen-activated protein kinase kinase kinase binding [IPI]
- phosphatase binding [ISO]
- phosphotyrosine binding [ISO]
- protein binding [IPI]
- protein kinase activity [ISO]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IC, IDA, ISO, TAS]
- transcription factor binding [IPI]
- ATP binding [IDA]
- MAP kinase activity [IDA, IMP, ISO, TAS]
- RNA polymerase II carboxy-terminal domain kinase activity [ISO]
- kinase activity [ISO, TAS]
- mitogen-activated protein kinase kinase kinase binding [IPI]
- phosphatase binding [ISO]
- phosphotyrosine binding [ISO]
- protein binding [IPI]
- protein kinase activity [ISO]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IC, IDA, ISO, TAS]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
- Golgi apparatus [TAS]
- axon [IDA]
- caveola [TAS]
- cytoplasm [ISO, ISS]
- cytoskeleton [TAS]
- cytosol [IDA, ISO, TAS]
- dendrite cytoplasm [IDA]
- early endosome [TAS]
- extracellular vesicular exosome [ISO]
- focal adhesion [TAS]
- late endosome [TAS]
- microtubule cytoskeleton [ISO]
- mitochondrion [ISO, TAS]
- mitotic spindle [ISS]
- nucleoplasm [IDA, ISO, TAS]
- nucleus [IDA, ISO, TAS]
- perikaryon [IDA]
- protein complex [IDA]
- pseudopodium [ISO]
Rattus norvegicus
PREY
TNFRSF1A
CD120a, FPF, TNF-R, TNF-R-I, TNF-R1, TNF-R55, TNF-alphaR1, TNFAR, TNFR60, TNFRI, TNFRp55, TNFalpha-R1, Tnfr-2, Tnfr1, p55, p55-R
tumor necrosis factor receptor superfamily, member 1a
GO Process (23)
GO Function (5)
GO Component (13)
Gene Ontology Biological Process
- cell surface receptor signaling pathway [IMP]
- cytokine-mediated signaling pathway [IMP]
- defense response [IMP]
- defense response to bacterium [IMP]
- inflammatory response [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of inflammatory response [ISO]
- negative regulation of interleukin-6 production [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of inflammatory response [IMP]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of protein import into nucleus, translocation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- positive regulation of tumor necrosis factor production [ISO]
- positive regulation of tyrosine phosphorylation of Stat1 protein [ISO]
- programmed cell death [IPI]
- prostaglandin metabolic process [TAS]
- protein heterooligomerization [ISO]
- regulation of apoptotic process [ISO]
- tumor necrosis factor-mediated signaling pathway [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Hierarchical phosphorylation of the TNF-alpha receptor, TNF-R1, by p42Mapk/Erk at basic Pro-directed kinase sites.
Phosphorylation of the TNF-alpha receptor TNF-R1 has been shown to differentially regulate receptor signaling and function and promote changes in its subcellular localization. Previous studies have shown that p42(mapk/erk2) phosphorylates Ser and Thr residues (T236, S240, S244, and S270) in the membrane proximal region of TNF-R1 and that mutation of these residues to Glu and Asp residues (TNF-R1.4D/E) mimics the ... [more]
Biochemistry May. 10, 2005; 44(18);6980-9 [Pubmed: 15865443]
Throughput
- Low Throughput
Curated By
- BioGRID