A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.

Publication

Polyglutamine-rich suppressors of huntingtin toxicity act upstream of Hsp70 and Sti1 in spatial quality control of amyloid-like proteins.

Wolfe KJ, Ren HY, Trepte P, Cyr DM

Protein conformational maladies such as Huntington Disease are characterized by accumulation of intracellular and extracellular protein inclusions containing amyloid-like proteins. There is an inverse correlation between proteotoxicity and aggregation, so facilitated protein aggregation appears cytoprotective. To define mechanisms for protective protein aggregation, a screen for suppressors of nuclear huntingtin (Htt103Q) toxicity was conducted. Nuclear Htt103Q is highly toxic and less ... [more]

PLoS ONE May. 16, 2014; 9(5);e95914 [Pubmed: 24828240]

Throughput

Low Throughput

Ontology Terms

phenotype: vegetative growth (APO:0000106)

Additional Notes

yeast high-copy suppressor screen of Htt103Q expressed in yeast

Curated By

BioGRID

Interaction Summary

HTT

Gene Ontology Biological Process

Gene Ontology Molecular Function

beta-tubulin binding [IDA]dynactin binding [IPI]dynein intermediate chain binding [IDA]identical protein binding [IPI]ion channel binding [IDA]p53 binding [IPI]protein binding [IPI]transcription factor binding [IBA]

Gene Ontology Cellular Component

POP2