RNF41
Gene Ontology Biological Process
- extrinsic apoptotic signaling pathway [IDA]
- negative regulation of cell migration [IMP]
- negative regulation of cell proliferation [IDA]
- positive regulation of reactive oxygen species metabolic process [IMP]
- proteasomal protein catabolic process [IDA]
- protein autoubiquitination [IDA]
- protein polyubiquitination [IDA]
- regulation of MAPK cascade [IDA]
- regulation of protein kinase B signaling [IDA]
- regulation of reactive oxygen species metabolic process [IMP]
Gene Ontology Molecular Function
HOMER2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
RNF41 interacts with the VPS52 subunit of the GARP and EARP complexes.
RNF41 (Ring Finger Protein 41) is an E3 ubiquitin ligase involved in the intracellular sorting and function of a diverse set of substrates. Next to BRUCE and Parkin, RNF41 can directly ubiquitinate ErbB3, IL-3, EPO and RARα receptors or downstream signaling molecules such as Myd88, TBK1 and USP8. In this way it can regulate receptor signaling and routing. To further ... [more]
Throughput
- Low Throughput
Additional Notes
- interaction identified in Mammalian Protein-Protein Interaction Trap (MAPPIT)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RNF41 HOMER2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| RNF41 HOMER2 | PCA PCA A Protein-Fragment Complementation Assay (PCA) is a protein-protein interaction assay in which a bait protein is expressed as fusion to one of the either N- or C- terminal peptide fragments of a reporter protein and prey protein is expressed as fusion to the complementary N- or C- terminal fragment of the same reporter protein. Interaction of bait and prey proteins bring together complementary fragments, which can then fold into an active reporter, e.g. the split-ubiquitin assay. | High | - | BioGRID | 2447725 | |
| HOMER2 RNF41 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID