BAIT
EZH2
Enx-1, Enx1h, KMT6, mKIAA4065
enhancer of zeste homolog 2 (Drosophila)
GO Process (29)
GO Function (9)
GO Component (6)
Gene Ontology Biological Process
- DNA methylation [IMP]
- G1 to G0 transition [IMP]
- cellular response to hydrogen peroxide [IDA]
- cerebellar cortex development [IMP]
- histone H3-K27 methylation [IMP, ISO]
- histone methylation [IDA]
- negative regulation of G1/S transition of mitotic cell cycle [IMP]
- negative regulation of epidermal cell differentiation [IMP]
- negative regulation of gene expression [ISO]
- negative regulation of gene expression, epigenetic [ISO]
- negative regulation of retinoic acid receptor signaling pathway [ISO]
- negative regulation of striated muscle cell differentiation [IDA]
- negative regulation of transcription elongation from RNA polymerase II promoter [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of Ras GTPase activity [ISO]
- positive regulation of dendrite development [ISO]
- positive regulation of epithelial to mesenchymal transition [ISO]
- positive regulation of protein serine/threonine kinase activity [ISO]
- protein localization to chromatin [IMP]
- regulation of cell proliferation [IMP]
- regulation of circadian rhythm [IMP, ISO]
- regulation of gene expression [IMP]
- regulation of gliogenesis [IMP]
- regulation of neurogenesis [IMP]
- regulation of protein phosphorylation [IMP]
- regulation of transcription from RNA polymerase II promoter [IMP]
- skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
DBT
D3Wsu60e
dihydrolipoamide branched chain transacylase E2
GO Process (0)
GO Function (0)
GO Component (2)
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator.
Cell-type specific gene silencing by histone H3 lysine 27 and lysine 9 methyltransferase complexes PRC2 and G9A-GLP is crucial both during development and to maintain cell identity. Although studying their interaction partners has yielded valuable insight into their functions, how these factors are regulated on a network level remains incompletely understood. Here, we present a new approach that combines quantitative ... [more]
Mol. Cell Proteomics Jun. 01, 2015; 14(6);1435-46 [Pubmed: 25680957]
Throughput
- High Throughput
Curated By
- BioGRID