SUZ12
Gene Ontology Biological Process
- histone H3-K27 trimethylation [ISO]
- histone methylation [IMP]
- histone ubiquitination [IMP]
- negative regulation of cell differentiation [ISO]
- negative regulation of chemokine production [ISO]
- negative regulation of epithelial cell proliferation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of tyrosine phosphorylation of Stat3 protein [ISO]
- positive regulation of cell proliferation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- ESC/E(Z) complex [IDA, ISO]
- nucleolus [ISO]
- nucleus [IDA, ISO]
- sex chromatin [IDA]
MTF2
Gene Ontology Biological Process
- negative regulation of histone H3-K27 methylation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of histone H3-K27 methylation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- segment specification [IMP]
- stem cell differentiation [IMP]
- stem cell maintenance [IMP]
Gene Ontology Molecular Function
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator.
Cell-type specific gene silencing by histone H3 lysine 27 and lysine 9 methyltransferase complexes PRC2 and G9A-GLP is crucial both during development and to maintain cell identity. Although studying their interaction partners has yielded valuable insight into their functions, how these factors are regulated on a network level remains incompletely understood. Here, we present a new approach that combines quantitative ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SUZ12 MTF2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | 669467 | |
| MTF2 SUZ12 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| SUZ12 MTF2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 669478 | |
| MTF2 SUZ12 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 669479 |
Curated By
- BioGRID