BAIT
EHMT2
Bat8, D17Ertd710e, G9a, KMT1C, NG36, RP23-349B4.3
euchromatic histone lysine N-methyltransferase 2
GO Process (21)
GO Function (8)
GO Component (6)
Gene Ontology Biological Process
- DNA methylation [IDA]
- DNA methylation on cytosine within a CG sequence [IMP]
- cellular response to drug [ISO]
- fertilization [IMP]
- germ cell development [IMP]
- histone H3-K27 methylation [IDA, IMP]
- histone H3-K9 methylation [IDA, IMP]
- histone lysine methylation [ISO]
- histone methylation [IMP, ISO]
- long-term memory [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- organ growth [IMP]
- peptidyl-lysine dimethylation [ISO]
- peptidyl-lysine methylation [IMP]
- regulation of DNA methylation [ISO]
- regulation of DNA replication [IMP, ISO]
- regulation of histone H3-K4 methylation [ISO]
- regulation of histone H3-K9 methylation [ISO]
- regulation of transcription from RNA polymerase II promoter [IMP]
- spermatid development [IMP]
- synaptonemal complex assembly [IMP]
Gene Ontology Molecular Function- C2H2 zinc finger domain binding [IPI, ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- histone methyltransferase activity (H3-K27 specific) [IDA]
- histone methyltransferase activity (H3-K9 specific) [IDA, IMP]
- histone-lysine N-methyltransferase activity [IDA, IMP, ISO]
- p53 binding [ISO]
- protein binding [IPI]
- protein-lysine N-methyltransferase activity [ISO]
- C2H2 zinc finger domain binding [IPI, ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- histone methyltransferase activity (H3-K27 specific) [IDA]
- histone methyltransferase activity (H3-K9 specific) [IDA, IMP]
- histone-lysine N-methyltransferase activity [IDA, IMP, ISO]
- p53 binding [ISO]
- protein binding [IPI]
- protein-lysine N-methyltransferase activity [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
UHRF1
AL022808, ICBP90, Np95, RNF106
ubiquitin-like, containing PHD and RING finger domains, 1
GO Process (8)
GO Function (11)
GO Component (9)
Gene Ontology Biological Process
- cell proliferation [TAS]
- histone monoubiquitination [IDA]
- histone ubiquitination [ISO]
- maintenance of DNA methylation [IMP, ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of cellular protein metabolic process [ISO]
- protein autoubiquitination [ISO]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO]
Gene Ontology Molecular Function- core promoter proximal region sequence-specific DNA binding [ISO]
- hemi-methylated DNA-binding [IDA, ISO]
- histone binding [ISO]
- identical protein binding [IPI]
- methyl-CpG binding [ISO]
- methylated histone binding [IDA, ISO]
- nucleosomal histone binding [IDA]
- protein binding [IPI]
- ubiquitin protein ligase activity [IDA]
- ubiquitin-protein transferase activity [IDA, ISO]
- zinc ion binding [ISO]
- core promoter proximal region sequence-specific DNA binding [ISO]
- hemi-methylated DNA-binding [IDA, ISO]
- histone binding [ISO]
- identical protein binding [IPI]
- methyl-CpG binding [ISO]
- methylated histone binding [IDA, ISO]
- nucleosomal histone binding [IDA]
- protein binding [IPI]
- ubiquitin protein ligase activity [IDA]
- ubiquitin-protein transferase activity [IDA, ISO]
- zinc ion binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator.
Cell-type specific gene silencing by histone H3 lysine 27 and lysine 9 methyltransferase complexes PRC2 and G9A-GLP is crucial both during development and to maintain cell identity. Although studying their interaction partners has yielded valuable insight into their functions, how these factors are regulated on a network level remains incompletely understood. Here, we present a new approach that combines quantitative ... [more]
Mol. Cell Proteomics Jun. 01, 2015; 14(6);1435-46 [Pubmed: 25680957]
Throughput
- High Throughput
Curated By
- BioGRID