EHMT2
Gene Ontology Biological Process
- DNA methylation [IDA]
- DNA methylation on cytosine within a CG sequence [IMP]
- cellular response to drug [ISO]
- fertilization [IMP]
- germ cell development [IMP]
- histone H3-K27 methylation [IDA, IMP]
- histone H3-K9 methylation [IDA, IMP]
- histone lysine methylation [ISO]
- histone methylation [IMP, ISO]
- long-term memory [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- organ growth [IMP]
- peptidyl-lysine dimethylation [ISO]
- peptidyl-lysine methylation [IMP]
- regulation of DNA methylation [ISO]
- regulation of DNA replication [IMP, ISO]
- regulation of histone H3-K4 methylation [ISO]
- regulation of histone H3-K9 methylation [ISO]
- regulation of transcription from RNA polymerase II promoter [IMP]
- spermatid development [IMP]
- synaptonemal complex assembly [IMP]
Gene Ontology Molecular Function- C2H2 zinc finger domain binding [IPI, ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- histone methyltransferase activity (H3-K27 specific) [IDA]
- histone methyltransferase activity (H3-K9 specific) [IDA, IMP]
- histone-lysine N-methyltransferase activity [IDA, IMP, ISO]
- p53 binding [ISO]
- protein binding [IPI]
- protein-lysine N-methyltransferase activity [ISO]
- C2H2 zinc finger domain binding [IPI, ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- histone methyltransferase activity (H3-K27 specific) [IDA]
- histone methyltransferase activity (H3-K9 specific) [IDA, IMP]
- histone-lysine N-methyltransferase activity [IDA, IMP, ISO]
- p53 binding [ISO]
- protein binding [IPI]
- protein-lysine N-methyltransferase activity [ISO]
Gene Ontology Cellular Component
EZH1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- ESC/E(Z) complex [IDA, ISO]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator.
Cell-type specific gene silencing by histone H3 lysine 27 and lysine 9 methyltransferase complexes PRC2 and G9A-GLP is crucial both during development and to maintain cell identity. Although studying their interaction partners has yielded valuable insight into their functions, how these factors are regulated on a network level remains incompletely understood. Here, we present a new approach that combines quantitative ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| EZH1 EHMT2 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID